Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains. - Wikidata - awgldk - TriplyDB

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains.

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains.

http://www.wikidata.org/entity/Q43156404

about

Assembly of Bak homodimers into higher order homooligomers in the mitochondrial apoptotic pore Expression levels of the BAK1 and BCL2 genes highlight the role of apoptosis in age-related hearing impairment Release of Cytochrome C from Bax Pores at the Mitochondrial Membrane.BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane.Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies.Conformational Heterogeneity of Bax Helix 9 Dimer for Apoptotic Pore Formation Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes.The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane.Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins.Disordered clusters of Bak dimers rupture mitochondria during apoptosis.Pore formation by dimeric Bak and Bax: an unusual pore?The Bcl-2 Family in Host-Virus Interactions.The BCL-2 arbiters of apoptosis and their growing role as cancer targets.Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion.BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove.Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies.

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P2860

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains.

http://www.wikidata.org/entity/Q43156404

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2015 nî lūn-bûn

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Cell Death & Differentiation

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P2093

D Westphal

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F Bell

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P2860

Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol

BH3 domains other than Bim and Bid can directly activate Bax/Bak

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

Conformation of the Bax C-terminus regulates subcellular location and cell death

Movement of Bax from the cytosol to mitochondria during apoptosis

Structure of Bax: coregulation of dimer formation and intracellular localization

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle

BAX activation is initiated at a novel interaction site

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

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