Architecture and conformational switch mechanism of the ryanodine receptor
about
Cryo-EM studies of the structure and dynamics of vacuolar-type ATPasesCalcium Signaling in Oomycetes: An Evolutionary PerspectiveElectron Microscopy: From 2D to 3D Images with Special Reference to MuscleMembrane protein structures without crystals, by single particle electron cryomicroscopyA saposin-lipoprotein nanoparticle system for membrane proteins.Membrane insertion of a Tc toxin in near-atomic detailStructural Basis for Gating and Activation of RyR1.TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid actionSingle-particle electron microscopy in the study of membrane protein structureInsight towards the identification of cytosolic Ca2+ -binding sites in ryanodine receptors from skeletal and cardiac muscle.The changing landscape of membrane protein structural biology through developments in electron microscopy.Muscling in on the ryanodine receptor.Single-Particle Cryo-EM at Crystallographic ResolutionThe H29D Mutation Does Not Enhance Cytosolic Ca2+ Activation of the Cardiac Ryanodine ReceptorChannel Gating Dependence on Pore Lining Helix Glycine Residues in Skeletal Muscle Ryanodine ReceptorCrystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant.Following Natures Lead: On the Construction of Membrane-Inserted Toxins in Lipid Bilayer Nanodiscs.Cryo-electron microscopy and X-ray crystallography: complementary approaches to structural biology and drug discovery.The EF-hand Ca2+ Binding Domain Is Not Required for Cytosolic Ca2+ Activation of the Cardiac Ryanodine Receptor.Distinct Components of Retrograde Ca(V)1.1-RyR1 Coupling Revealed by a Lethal Mutation in RyR1.Gating machinery of InsP3R channels revealed by electron cryomicroscopyThe link between abnormal calcium handling and electrical instability in acquired long QT syndrome--Does calcium precipitate arrhythmic storms?Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands.In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptideThe Central domain of RyR1 is the transducer for long-range allosteric gating of channel openingStructural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1.Unravelling biological macromolecules with cryo-electron microscopy.Conformational Dynamics in FKBP Domains: Relevance to Molecular Signaling and Drug DesignStructure of IP3R channel: high-resolution insights from cryo-EM.Investigating the inter-subunit/subdomain interactions and motions relevant to disease mutations in the N-terminal domain of ryanodine receptors by molecular dynamics simulation.FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: Insights from new functional and structural knowledge.Malignant hyperthermia-associated mutations in the S2-S3 cytoplasmic loop of type 1 ryanodine receptor calcium channel impair calcium-dependent inactivation.Wnt3a nanodisks promote ex vivo expansion of hematopoietic stem and progenitor cellsThe principle of conformational signaling.Nanodiscs for structural and functional studies of membrane proteins.Why Calcium? How Calcium Became the Best Communicator.Toward decrypting the allosteric mechanism of the ryanodine receptor based on coarse-grained structural and dynamic modeling.A guide to the 3D structure of the ryanodine receptor type 1 by cryoEM.While the revolution will not be crystallized, biochemistry reigns supreme.Structures of the colossal RyR1 calcium release channel.
P2860
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P2860
Architecture and conformational switch mechanism of the ryanodine receptor
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Architecture and conformational switch mechanism of the ryanodine receptor
@ast
Architecture and conformational switch mechanism of the ryanodine receptor
@en
Architecture and conformational switch mechanism of the ryanodine receptor
@nl
type
label
Architecture and conformational switch mechanism of the ryanodine receptor
@ast
Architecture and conformational switch mechanism of the ryanodine receptor
@en
Architecture and conformational switch mechanism of the ryanodine receptor
@nl
prefLabel
Architecture and conformational switch mechanism of the ryanodine receptor
@ast
Architecture and conformational switch mechanism of the ryanodine receptor
@en
Architecture and conformational switch mechanism of the ryanodine receptor
@nl
P50
P3181
P356
P1433
P1476
Architecture and conformational switch mechanism of the ryanodine receptor
@en
P2888
P3181
P356
10.1038/NATURE13916
P407
P577
2015-01-01T00:00:00Z
P6179
1033151722