Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase
about
Chemical genetics approaches for selective intervention in epigeneticsA novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligaseEstablished and emerging targeted therapies in the myelodysplastic syndromes.Selective degradation of splicing factor CAPERα by anticancer sulfonamides.Induced protein degradation: an emerging drug discovery paradigm.Structural basis of PROTAC cooperative recognition for selective protein degradationChemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathwayCrystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.The impact of structural biology in medicine illustrated with four case studies.Activation of c-Abl Kinase Potentiates the Anti-myeloma Drug Lenalidomide by Promoting DDA1 Protein Recruitment to the CRL4 Ubiquitin Ligase.The molecular mechanism of thalidomide analogs in hematologic malignancies.Targeted Protein Degradation by Small Molecules.The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma.Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6.Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction.pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase.Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity.The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage.Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).FOXF1 defines the core-regulatory circuitry in gastrointestinal stromal tumor (GIST).Structural Insights into TCTP and Its Interactions with Ligands and Proteins.Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders.Stabilization of protein-protein interactions in drug discovery.The Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon-mediated Repression of AMPK Activity.Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E).Structural basis of thalidomide enantiomer binding to cereblon.Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.Pirh2 mediates the sensitivity of myeloma cells to bortezomib via canonical NF-κB signaling pathway.Downregulation of the IFNAR1 chain of type 1 interferon receptor contributes to the maintenance of the haematopoietic stem cells.Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC).Targeted protein degradation: You can glue it too!The role of p53 in myelodysplastic syndromes and acute myeloid leukemia: molecular aspects and clinical implications.Casein kinase 1α: biological mechanisms and theranostic potential.Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy.Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndromeUnlocking a dark pastUBE2G1 governs the destruction of cereblon neomorphic substrates
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P2860
Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase
description
2016 nî lūn-bûn
@nan
2016 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Structural basis of lenalidomi ...... he CRL4(CRBN) ubiquitin ligase
@ast
Structural basis of lenalidomi ...... he CRL4(CRBN) ubiquitin ligase
@en
Structural basis of lenalidomi ...... he CRL4(CRBN) ubiquitin ligase
@nl
type
label
Structural basis of lenalidomi ...... he CRL4(CRBN) ubiquitin ligase
@ast
Structural basis of lenalidomi ...... he CRL4(CRBN) ubiquitin ligase
@en
Structural basis of lenalidomi ...... he CRL4(CRBN) ubiquitin ligase
@nl
prefLabel
Structural basis of lenalidomi ...... he CRL4(CRBN) ubiquitin ligase
@ast
Structural basis of lenalidomi ...... he CRL4(CRBN) ubiquitin ligase
@en
Structural basis of lenalidomi ...... he CRL4(CRBN) ubiquitin ligase
@nl
P2860
P3181
P356
P1433
P1476
Structural basis of lenalidomi ...... he CRL4(CRBN) ubiquitin ligase
@en
P2093
Nicolas H Thomä
P2860
P2888
P304
P3181
P356
10.1038/NATURE16979
P407
P577
2016-04-07T00:00:00Z
P6179
1027760858