Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases
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Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyraseAntibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase.Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria.A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii.Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry.Novel Bacterial Topoisomerase Inhibitors Exploit Asp83 and the Intrinsic Flexibility of the DNA Gyrase Binding Site.DNA Topoisomerases as Targets for Antibacterial Agents.Topoisomerases as anticancer targets.
P2860
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P2860
Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases
description
2016 nî lūn-bûn
@nan
2016 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Novel tricyclics (e.g., GSK945 ...... terial type IIA topoisomerases
@ast
Novel tricyclics (e.g., GSK945 ...... terial type IIA topoisomerases
@en
Novel tricyclics (e.g., GSK945 ...... terial type IIA topoisomerases
@nl
type
label
Novel tricyclics (e.g., GSK945 ...... terial type IIA topoisomerases
@ast
Novel tricyclics (e.g., GSK945 ...... terial type IIA topoisomerases
@en
Novel tricyclics (e.g., GSK945 ...... terial type IIA topoisomerases
@nl
prefLabel
Novel tricyclics (e.g., GSK945 ...... terial type IIA topoisomerases
@ast
Novel tricyclics (e.g., GSK945 ...... terial type IIA topoisomerases
@en
Novel tricyclics (e.g., GSK945 ...... terial type IIA topoisomerases
@nl
P2093
P1476
Novel tricyclics (e.g., GSK945 ...... terial type IIA topoisomerases
@en
P2093
Alan J Hennessy
Barry S Brown
David T Davies
Dongzhao Chen
Elisabeth A Minthorn
Gerald Brooks
Graham E Jones
Ilaria Giordano
Joel M Esken
Michael N Gwynn
P304
P356
10.1016/J.BMCL.2016.03.106
P407
P577
2016-03-31T00:00:00Z