Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
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Protein prenyltransferasesThe crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimeticsStructure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathioneBornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase.Structural basis for the promiscuous biosynthetic prenylation of aromatic natural productsStructure of mammalian protein geranylgeranyltransferase type-IFarnesyl transferase inhibitor resistance probed by target mutagenesisCrystal structure of a class I α1,2-mannosidase involved in N-glycan processing and endoplasmic reticulum quality controlCrystal structure of cis-prenyl chain elongating enzyme, undecaprenyl diphosphate synthaseReaction path of protein farnesyltransferase at atomic resolutionStructure of tRNA Dimethylallyltransferase: RNA Modification through a ChannelMetal active site elasticity linked to activation of homocysteine in methionine synthasesStructure of Protein Geranylgeranyltransferase-I from the Human Pathogen Candida albicans Complexed with a Lipid SubstrateStructures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal PathogensCrystal structures of the fungal pathogenAspergillus fumigatusprotein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug designSubstrate specificity determinants in the farnesyltransferase beta-subunit.Lysine(164)alpha of protein farnesyltransferase is important for both CaaX substrate binding and catalysisCombination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cellsInactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: cleavage of the common alpha subunit during apoptosisRole of isoprenoid lipids on the heterotrimeric G protein gamma subunit in determining effector activation.Simple sequences are rare in the Protein Data Bank.Multiple domain insertions and losses in the evolution of the Rab prenylation complex.Cloning of the Arabidopsis WIGGUM gene identifies a role for farnesylation in meristem development.The CaaX specificities of Arabidopsis protein prenyltransferases explain era1 and ggb phenotypesTargeting protein prenylation for cancer therapyThe alpha-subunit of protein prenyltransferases is a member of the tetratricopeptide repeat family.Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma bruceiStructure, mechanism and function of prenyltransferases.A two-state piezoelectric model for outer hair cell motility.Piezoelectric reciprocal relationship of the membrane motor in the cochlear outer hair cellFarnesyltransferase--new insights into the zinc-coordination sphere paradigm: evidence for a carboxylate-shift mechanism.SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures.Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferaseStructure and mechanism of lanthipeptide biosynthetic enzymes.Murine guanylate-binding protein: incomplete geranylgeranyl isoprenoid modification of an interferon-gamma-inducible guanosine triphosphate-binding proteinUnearthing the roots of the terpenomeA defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.Therapeutic efficacy of prenylation inhibitors in the treatment of myeloid leukemia.A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans.The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformation
P2860
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P2860
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
@ast
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
@en
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
@nl
type
label
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
@ast
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
@en
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
@nl
prefLabel
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
@ast
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
@en
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
@nl
P2093
P3181
P1433
P1476
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
@en
P2093
P304
P3181
P356
10.1126/SCIENCE.275.5307.1800
P407
P577
1997-03-21T00:00:00Z