about
Testing electrostatic complementarity in enzyme catalysis: hydrogen bonding in the ketosteroid isomerase oxyanion holeFundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymesRoles of dimerization in folding and stability of ketosteroid isomerase from Pseudomonas putida biotype BCrystal structure of delta(5)-3-ketosteroid isomerase from Pseudomonas testosteroni in complex with equilenin settles the correct hydrogen bonding scheme for transition state stabilizationDetection of large pKa perturbations of an inhibitor and a catalytic group at an enzyme active site, a mechanistic basis for catalytic power of many enzymesOrigin of the different pH activity profile in two homologous ketosteroid isomerasesThe conserved cis-Pro39 residue plays a crucial role in the proper positioning of the catalytic base Asp38 in ketosteroid isomerase from Comamonas testosteroniHydrogen Bond Coupling in the Ketosteroid Isomerase Active SiteConversion of Human Steroid 5 -Reductase (AKR1D1) into 3 -Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERINGRescue of deleterious mutations by the compensatory Y30F mutation in ketosteroid isomeraseQuantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active siteUse of anion-aromatic interactions to position the general base in the ketosteroid isomerase active siteIdentification of a catalytic aspartyl residue of D-ribulose 5-phosphate 3-epimerase by site-directed mutagenesisMechanism-based inactivation of human glutaryl-CoA dehydrogenase by 2-pentynoyl-CoA: rationale for enhanced reactivity.Anesthetic interaction with ketosteroid isomerase: insights from molecular dynamics simulations.Reaction mechanism and stereochemistry of gamma-hexachlorocyclohexane dehydrochlorinase LinA.The isomerization of Δ5-androstene-3,17-dione by the human glutathione transferase A3-3 proceeds via a conjugated heteroannular diene intermediateDetermining the catalytic role of remote substrate binding interactions in ketosteroid isomerase.Contribution of a low-barrier hydrogen bond to catalysis is not significant in ketosteroid isomerase.Catalytic role of enzymes: short strong H-bond-induced partial proton shuttles and charge redistributions.On roads not taken in the evolution of protein catalysts: antibody steroid isomerases that use an enamine mechanismMolecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase IIExperimental and computational mutagenesis to investigate the positioning of a general base within an enzyme active site.A fascination with enzymes: the journey not the arrival matters.Mutational analysis of the three cysteines and active-site aspartic acid 103 of ketosteroid isomerase from Pseudomonas putida biotype B.Sequential Enzymatic Conversion of α-Angelica Lactone to γ-Valerolactone through Hydride-Independent C=C Bond Isomerization.Crystallization and preliminary X-ray analysis of gamma-hexachlorocyclohexane dehydrochlorinase LinA from Sphingobium japonicum UT26Mechanism of an antibody-catalysed allylic isomerization.Structural double-mutant cycle analysis of a hydrogen bond network in ketosteroid isomerase from Pseudomonas putida biotype B.Impact of mutation on proton transfer reactions in ketosteroid isomerase: insights from molecular dynamics simulationsHybrid quantum/classical molecular dynamics simulations of the proton transfer reactions catalyzed by ketosteroid isomerase: analysis of hydrogen bonding, conformational motions, and electrostatics.QM/MM modelling of ketosteroid isomerase reactivity indicates that active site closure is integral to catalysis.Trifluoroethanol increases the stability of Delta(5)-3-ketosteroid isomerase. 15N NMR relaxation studies.Theoretical study of enzymatically catalyzed tautomerization of carbon acids in aqueous solution: quantum calculations and steered molecular dynamics simulations.Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases
P2860
Q21146064-C4B7348C-FC05-45E5-8D47-B25AF5112073Q24289386-B2041CB0-6EB8-4218-9A3F-768736F33343Q24644636-E98E7F78-3CB3-46F5-B6DA-90B285C4F59DQ27620291-EE8C6E7F-517F-49B6-BDC2-17661F98E2D5Q27627242-B22B5FBC-E635-49DD-B3CE-D398B22AF6E7Q27641168-9B276E05-2291-4B67-9BE9-CE06C8FC87A8Q27641652-BF8997E2-3749-4B35-88B4-37EB805DD9BEQ27655611-ADEE1BB4-ABD7-489B-B85D-945101D37490Q27678144-26E4EF9D-FF8E-4FCA-9178-2C51577B7390Q27678507-0598F400-2C87-4C92-9545-7A8D8A3E8FF9Q27678764-C7D471E1-3741-4964-9FC8-60A9F57C531AQ27678777-8EF321DE-6754-4745-9758-07F644E4506BQ28294089-5B6A15AF-5ABB-4F0E-8B1B-114F14DBCBECQ30920541-A8816355-8093-48A7-A61F-83CE3BCBC0D8Q30995948-E24C9F9F-AE93-4DC7-B5F3-FEE21CEEEF2EQ31636638-5A513948-FE4B-44A0-906C-939D937604D1Q34509826-3E361197-674D-45F8-A640-F29101E10E9EQ34999380-40DE6995-81FE-4ED0-8F34-E3769B832DABQ35644462-652DFF32-5D5F-4440-BFBA-62F1C45C04EBQ35771925-2C08CE18-DE40-4AE3-A2A7-39C30522BF78Q36604899-E395A4CF-39F9-4B43-A2BE-43003C2E2BE0Q36879246-58D5DB0A-4CC9-45D9-888E-30D1D00A34DCQ37731565-AEC831CB-FBD5-4AF8-B611-8A6D3A24CC33Q38575125-343B31B7-1BCD-4DEB-B12E-FB77C4A2D4D4Q39848266-8D1846DD-A929-4FC5-BF82-A416D224E676Q41541198-7B3B2235-DFF4-4C46-87D6-FD4F29DFF5DDQ41815272-59AFBA8E-5B9F-4AA7-9677-1421ADE23EC6Q41882638-EFD9EF6A-0C62-44C7-B03A-F946720D70C3Q41951008-184893AD-D586-4008-9699-1E3EB6CBACB7Q41957634-946BDC0C-2BFE-48CF-8167-E82111ABB490Q42672823-61973A89-5D27-475F-B0E6-20F72F9AA986Q43545904-B1247138-61F2-4574-995E-96CCBCA87899Q43969941-519E1E84-3C23-4596-8A43-B2DF9F7C7600Q50726248-0AF6DED2-62ED-4A04-A71C-E783FC8428F2Q57966415-A792DBD9-4C20-48D9-86AC-5ECC65271BD4
P2860
description
1997 nî lūn-bûn
@nan
1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Solution structure of 3-oxo-delta5-steroid isomerase
@ast
Solution structure of 3-oxo-delta5-steroid isomerase
@en
Solution structure of 3-oxo-delta5-steroid isomerase
@nl
type
label
Solution structure of 3-oxo-delta5-steroid isomerase
@ast
Solution structure of 3-oxo-delta5-steroid isomerase
@en
Solution structure of 3-oxo-delta5-steroid isomerase
@nl
prefLabel
Solution structure of 3-oxo-delta5-steroid isomerase
@ast
Solution structure of 3-oxo-delta5-steroid isomerase
@en
Solution structure of 3-oxo-delta5-steroid isomerase
@nl
P2093
P1433
P1476
Solution structure of 3-oxo-delta5-steroid isomerase
@en
P2093
G C Perez-Alvarado
L D Thornburg
M E Zawrotny
M F Summers
P Brothers
R M Pollack
S Ebrahimian
P356
10.1126/SCIENCE.276.5311.415
P407
P577
1997-04-18T00:00:00Z