The crystal structure of human interferon beta at 2.2-A resolution
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Interferon-kappa, a novel type I interferon expressed in human keratinocytesAmidation of Bioactive Peptides: The Structure of the Lyase Domain of the Amidating EnzymeIntermolecular Interactions in a 44 kDa Interferon−Receptor Complex Detected by Asymmetric Reverse-Protonation and Two-Dimensional NOESYCrystal Structure of Human Interferon-λ1 in Complex with Its High-Affinity Receptor Interferon-λR1Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation.Glycoengineering of interferon-β 1a improves its biophysical and pharmacokinetic propertiesInterferons and their receptors in birds: a comparison of gene structure, phylogenetic analysis, and cross modulationPharmacokinetic considerations in the treatment of multiple sclerosis with interferon-β.Effects of localized interactions and surface properties on stability of protein-based therapeutics.The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studiesOxidized and aggregated recombinant human interferon beta is immunogenic in human interferon beta transgenic mice.Minimal functional sites allow a classification of zinc sites in proteins.Stable high volumetric production of glycosylated human recombinant IFNalpha2b in HEK293 cells.Novel pegylated interferon-β as strong suppressor of the malignant ascites in a peritoneal metastasis model of human cancer.Conformation and dynamics of biopharmaceuticals: transition of mass spectrometry-based tools from academe to industry.Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking.Molecular and functional analysis of an interferon gene from the zebrafish, Danio rerioZinc binding to the Tyr402 and His402 allotypes of complement factor H: possible implications for age-related macular degeneration.The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases.Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex.Interferon-beta1b in multiple sclerosis.Identification of oxidation sites and covalent cross-links in metal catalyzed oxidized interferon Beta-1a: potential implications for protein aggregation and immunogenicitySite-specific PEGylation enhances the pharmacokinetic properties and antitumor activity of interferon beta-1b.Carbohydrate analysis throughout the development of a protein therapeutic.Interferon Lambda: Modulating Immunity in Infectious Diseases.Oxidation of therapeutic proteins and peptides: structural and biological consequences.The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections.Retinopathy during interferon-β treatment for multiple sclerosis: case report and review of the literature.Effect of Nonionic Surfactants (Dodecyl Maltoside and Polysorbate 20) on Prevention of Aggregation and Conformational Changes of Recombinant Human IFNβ_1b Induced by Light.Sequence-based protein stabilization in the absence of glycosylation.NMR mapping of the IFNAR1-EC binding site on IFNalpha2 reveals allosteric changes in the IFNAR2-EC binding site.Type I interferons in the treatment of pancreatic cancer: mechanisms of action and role of related receptors.Optimizing the binding affinity of a carrier protein: a case study on the interaction between soluble ifnar2 and interferon beta.Characterization of N-terminal interferon tau mutants: P26L affords enhanced activity and lack of toxicity.New structural and functional aspects of the type I interferon-receptor interaction revealed by comprehensive mutational analysis of the binding interface.Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab.Structural basis of the broadly neutralizing anti-interferon-α antibody rontalizumab.The EM structure of a type I interferon-receptor complex reveals a novel mechanism for cytokine signaling.Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-interferon antibody fragment and human interferon alpha-2A.Characterization of a soluble ternary complex formed between human interferon-beta-1a and its receptor chains.
P2860
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P2860
The crystal structure of human interferon beta at 2.2-A resolution
description
1997 nî lūn-bûn
@nan
1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
The crystal structure of human interferon beta at 2.2-A resolution
@ast
The crystal structure of human interferon beta at 2.2-A resolution
@en
The crystal structure of human interferon beta at 2.2-A resolution
@nl
type
label
The crystal structure of human interferon beta at 2.2-A resolution
@ast
The crystal structure of human interferon beta at 2.2-A resolution
@en
The crystal structure of human interferon beta at 2.2-A resolution
@nl
prefLabel
The crystal structure of human interferon beta at 2.2-A resolution
@ast
The crystal structure of human interferon beta at 2.2-A resolution
@en
The crystal structure of human interferon beta at 2.2-A resolution
@nl
P2093
P2860
P356
P1476
The crystal structure of human interferon beta at 2.2-A resolution
@en
P2093
P2860
P304
11813-11818
P356
10.1073/PNAS.94.22.11813
P407
P50
P577
1997-10-01T00:00:00Z