Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor
about
The T-box familyTBX22 missense mutations found in patients with X-linked cleft palate affect DNA binding, sumoylation, and transcriptional repressionHuman TBX1 missense mutations cause gain of function resulting in the same phenotype as 22q11.2 deletionsBrachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activityNovel mutation of TBX3 in a Japanese family with ulnar-mammary syndrome: implication for impaired sex developmentMutations in the T (brachyury) gene cause a novel syndrome consisting of sacral agenesis, abnormal ossification of the vertebral bodies and a persistent notochordal canalFunctional analysis of TBX5 missense mutations associated with Holt-Oram syndromeMutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter DevelopmentBrachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter.The spectrum of mutations in TBX3: Genotype/Phenotype relationship in ulnar-mammary syndrome.T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-siteSexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers.Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome mutationsAn overview of the structures of protein-DNA complexesThe T-box gene family: emerging roles in development, stem cells and cancerStructure of the sporulation-specific transcription factor Ndt80 bound to DNA.Crystallographic Analysis of a Sex-Specific Enhancer Element: Sequence-Dependent DNA Structure, Hydration, and DynamicsStructure of the DNA-bound T-box domain of human TBX1, a transcription factor associated with the DiGeorge syndromeThe gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytesThe T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiatorThe T-box factor MLS-1 acts as a molecular switch during specification of nonstriated muscle in C. elegansThe role of T‑box genes in the tumorigenesis and progression of cancer (Review)Mammalian TBX1 preferentially binds and regulates downstream targets via a tandem T-site repeatTbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormalityTbx19, a tissue-selective regulator of POMC gene expressionVertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNATranscriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressorsProtein interactions in human genetic diseases.Overview of protein structural and functional folds.An evolutionarily conserved nuclear export signal facilitates cytoplasmic localization of the Tbx5 transcription factor.Mapping and conformational characterization of the DNA-binding region of the breast cancer susceptibility protein BRCA1.From notochord formation to hereditary chordoma: the many roles of Brachyury.Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma.Reconstructing the history of human limb development: lessons from birth defects.The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells.A pituitary-specific enhancer of the POMC gene with preferential activity in corticotrope cells.Expressivity of Holt-Oram syndrome is not predicted by TBX5 genotypeXwnt11 and the regulation of gastrulation in Xenopus.T-targets: clues to understanding the functions of T-box proteins.Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki
P2860
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P2860
Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor
description
1997 nî lūn-bûn
@nan
1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
Crystallographic structure of ...... Brachyury transcription factor
@ast
Crystallographic structure of ...... Brachyury transcription factor
@en
Crystallographic structure of ...... Brachyury transcription factor
@nl
type
label
Crystallographic structure of ...... Brachyury transcription factor
@ast
Crystallographic structure of ...... Brachyury transcription factor
@en
Crystallographic structure of ...... Brachyury transcription factor
@nl
prefLabel
Crystallographic structure of ...... Brachyury transcription factor
@ast
Crystallographic structure of ...... Brachyury transcription factor
@en
Crystallographic structure of ...... Brachyury transcription factor
@nl
P356
P1433
P1476
Crystallographic structure of ...... Brachyury transcription factor
@en
P2093
B G Herrmann
C W Müller
P2888
P304
P356
10.1038/39929
P407
P577
1997-10-01T00:00:00Z
P6179
1009841769