The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells.
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Overexpression of brachyury contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinomaAndrogen-targeted therapy-induced epithelial mesenchymal plasticity and neuroendocrine transdifferentiation in prostate cancer: an opportunity for interventionBrachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancerThe IL-8/IL-8R Axis: A Double Agent in Tumor Immune ResistanceRecent advances in therapeutic cancer vaccinesFunctional Brachyury binding sites establish a temporal read-out of gene expression in the Ciona notochordInitial steps of metastasis: cell invasion and endothelial transmigrationNuances in the treatment of malignant tumors of the clival and petroclival region.Charting Brachyury-mediated developmental pathways during early mouse embryogenesis.Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target.An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.Novel therapeutic targets in chordoma.From notochord formation to hereditary chordoma: the many roles of Brachyury.Molecular and clinical risk factors for recurrence of skull base chordomas: gain on chromosome 2p, expression of brachyury, and lack of irradiation negatively correlate with patient prognosis.The brachyury Gly177Asp SNP is not associated with a risk of skull base chordoma in the Chinese population.The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival.An overview of the role of cancer stem cells in spine tumors with a special focus on chordoma.FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation.Novel targeted therapies in chordoma: an update.Nuclear Brachyury Expression Is Consistent in Chordoma, Common in Germ Cell Tumors and Small Cell Carcinomas, and Rare in Other Carcinomas and Sarcomas: An Immunohistochemical Study of 5229 CasesPhase I Trial of a Yeast-Based Therapeutic Cancer Vaccine (GI-6301) Targeting the Transcription Factor Brachyury.Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT.Genetic aberrations and molecular biology of skull base chordoma and chondrosarcoma.WEE1 inhibition alleviates resistance to immune attack of tumor cells undergoing epithelial-mesenchymal transition.Vaccines against human carcinomas: strategies to improve antitumor immune responses.Brachyury regulates proliferation of cancer cells via a p27Kip1-dependent pathwayThe T-box transcription factor Brachyury regulates epithelial-mesenchymal transition in association with cancer stem-like cells in adenoid cystic carcinoma cellsIdentification and characterization of a cytotoxic T-lymphocyte agonist epitope of brachyury, a transcription factor involved in epithelial to mesenchymal transition and metastasis.The T-box transcription factor Brachyury promotes renal interstitial fibrosis by repressing E-cadherin expression.Dynamic transcription factor networks in epithelial-mesenchymal transition in breast cancer models.MDM2 promotes invasion and metastasis in invasive ductal breast carcinoma by inducing matrix metalloproteinase-9.A novel role for the T-box transcription factor Tbx1 as a negative regulator of tumor cell growth in mice.IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cellsRepurposing the antipsychotic trifluoperazine as an antimetastasis agent.Spermatogonial stem cell self-renewal requires ETV5-mediated downstream activation of Brachyury in mice.Pan-cancer stratification of solid human epithelial tumors and cancer cell lines reveals commonalities and tissue-specific features of the CpG island methylator phenotypeImpact of Brachyury on epithelial-mesenchymal transitions and chemosensitivity in non-small cell lung cancer.Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody.Defining the molecular signature of chemotherapy-mediated lung tumor phenotype modulation and increased susceptibility to T-cell killing.Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells.
P2860
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P2860
The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The T-box transcription factor ...... ansition in human tumor cells.
@ast
The T-box transcription factor ...... ansition in human tumor cells.
@en
type
label
The T-box transcription factor ...... ansition in human tumor cells.
@ast
The T-box transcription factor ...... ansition in human tumor cells.
@en
prefLabel
The T-box transcription factor ...... ansition in human tumor cells.
@ast
The T-box transcription factor ...... ansition in human tumor cells.
@en
P2093
P2860
P356
P1476
The T-box transcription factor ...... ansition in human tumor cells.
@en
P2093
Claudia Palena
Duane H Hamilton
Jeffrey Schlom
Mary Litzinger
Paola Trono
Romaine I Fernando
P2860
P304
P356
10.1172/JCI38379
P407
P577
2010-01-11T00:00:00Z