Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site
about
Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursorThe post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A)Probing the function of the invariant glutamyl residue 312 in spinach ferredoxin-NADP+ reductaseMapping eIF5A binding sites for Dys1 and Lia1: in vivo evidence for regulation of eIF5A hypusination.Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthaseMolecular evolution by change of function. Alkaloid-specific homospermidine synthase retained all properties of deoxyhypusine synthase except binding the eIF5A precursor proteinA new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complexStructure-function studies of human deoxyhypusine synthase: identification of amino acid residues critical for the binding of spermidine and NADIdentification of novel components of NAD-utilizing metabolic pathways and prediction of their biochemical functions.Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax.Identification and characterization of a novel deoxyhypusine synthase in Leishmania donovani.Deoxyhypusine synthase from tobacco. cDNA isolation, characterization, and bacterial expression of an enzyme with extended substrate specificity.Deoxyhypusine synthase generates and uses bound NADH in a transient hydride transfer mechanism.Cryptosporidium parvum has an active hypusine biosynthesis pathway.The hypusine-containing translation factor eIF5A.The non-canonical hydroxylase structure of YfcM reveals a metal ion-coordination motif required for EF-P hydroxylation.Molecular cloning and functional expression of bovine deoxyhypusine hydroxylase cDNA and homologsDeciphering the Translation Initiation Factor 5A Modification Pathway in Halophilic Archaea.Spermidine-binding proteins. Purification and expression analysis in maize.A new non-radioactive deoxyhypusine synthase assay adaptable to high throughput screening.Comprehensive Structural Characterization of the Bacterial Homospermidine Synthase-an Essential Enzyme of the Polyamine Metabolism.Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates.In silico design, synthesis, and screening of novel deoxyhypusine synthase inhibitors targeting HIV-1 replication.Cloning and expression of a cDNA encoding homospermidine synthase from Senecio vulgaris (Asteraceae) in Escherichia coli.Repeated evolution of the pyrrolizidine alkaloid-mediated defense system in separate angiosperm lineages.Evolution of homospermidine synthase in the convolvulaceae: a story of gene duplication, gene loss, and periods of various selection pressures
P2860
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P2860
Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
name
Crystal structure of the NAD c ...... m for blocking the active site
@ast
Crystal structure of the NAD c ...... m for blocking the active site
@en
Crystal structure of the NAD c ...... m for blocking the active site
@nl
type
label
Crystal structure of the NAD c ...... m for blocking the active site
@ast
Crystal structure of the NAD c ...... m for blocking the active site
@en
Crystal structure of the NAD c ...... m for blocking the active site
@nl
prefLabel
Crystal structure of the NAD c ...... m for blocking the active site
@ast
Crystal structure of the NAD c ...... m for blocking the active site
@en
Crystal structure of the NAD c ...... m for blocking the active site
@nl
P2093
P1433
P1476
Crystal structure of the NAD c ...... m for blocking the active site
@en
P2093
P356
10.1016/S0969-2126(98)00004-5
P407
P577
1998-01-15T00:00:00Z