Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates
about
Duality of polynucleotide substrates for Phi29 DNA polymerase: 3'-->5' RNase activity of the enzymeMetal ion-mediated substrate-assisted catalysis in type II restriction endonucleasesSyntheses of 4'-thioribonucleosides and thermodynamic stability and crystal structure of RNA oligomers with incorporated 4'-thiocytosine.Structural origins of the exonuclease resistance of a zwitterionic RNATetramerization and ATP binding by a protein comprising the A, B, and C domains of rat synapsin IThe 1.4-A crystal structure of the S. pombe Pop2p deadenylase subunit unveils the configuration of an active enzymeSequential structures provide insights into the fidelity of RNA replicationStructural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleasesTesting Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion HoleStructures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease FamilyRecognition and processing of double-stranded DNA by ExoX, a distributive 3'-5' exonuclease3′-Processing and strand transfer catalysed by retroviral integrasein crystalloThe role of metals in catalysis by the restriction endonuclease BamHICoordination of divalent metal ions in the active site of poly(A)-specific ribonucleaseChloroplast ribonuclease P does not utilize the ribozyme-type pre-tRNA cleavage mechanismIdentification of the active site of poly(A)-specific ribonuclease by site-directed mutagenesis and Fe(2+)-mediated cleavageBackbone and nucleobase contacts to glucosamine-6-phosphate in the glmS ribozymeA novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestineA nuclear family A DNA polymerase from Entamoeba histolytica bypasses thymine glycolRecent advances in the elucidation of the mechanisms of action of ribozymesDNA polymerases: structural diversity and common mechanismsShared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallographySingle base extension (SBE) with proofreading polymerases and phosphorothioate primers: improved fidelity in single-substrate assaysProbing biomolecular structures and dynamics of single molecules using in-gel alternating-laser excitation.A further investigation and reappraisal of the thio effect in the cleavage reaction catalyzed by a hammerhead ribozyme.The use of divalent metal ions by type II topoisomerases.Unified two-metal mechanism of RNA synthesis and degradation by RNA polymerase.Thiophilic metal ion rescue of phosphorothioate interference within the Tetrahymena ribozyme P4-P6 domain.Helix P4 is a divalent metal ion binding site in the conserved core of the ribonuclease P ribozyme.An unconventional origin of metal-ion rescue and inhibition in the Tetrahymena group I ribozyme reaction.Specific phosphorothioate substitutions probe the active site of Bacillus subtilis ribonuclease P.Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease.Calcium inhibition of ribonuclease H1 two-metal ion catalysisCrystal structure of the moloney murine leukemia virus RNase H domainSite-specific DNA transesterification catalyzed by a restriction enzyme.Single-molecule and ensemble fluorescence assays for a functionally important conformational change in T7 DNA polymerase.A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase.Structure of the nuclear exosome component Rrp6p reveals an interplay between the active site and the HRDC domainStructure of a GDP:AlF4 complex of the SRP GTPases Ffh and FtsY, and identification of a peripheral nucleotide interaction siteIdentification of c-di-GMP derivatives resistant to an EAL domain phosphodiesterase
P2860
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P2860
Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
name
Structural principles for the ...... ymerase I by phosphorothioates
@ast
Structural principles for the ...... ymerase I by phosphorothioates
@en
Structural principles for the ...... ymerase I by phosphorothioates
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type
label
Structural principles for the ...... ymerase I by phosphorothioates
@ast
Structural principles for the ...... ymerase I by phosphorothioates
@en
Structural principles for the ...... ymerase I by phosphorothioates
@nl
prefLabel
Structural principles for the ...... ymerase I by phosphorothioates
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Structural principles for the ...... ymerase I by phosphorothioates
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Structural principles for the ...... ymerase I by phosphorothioates
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P3181
P356
P1476
Structural principles for the ...... ymerase I by phosphorothioates
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P2093
C A Brautigam
T A Steitz
P304
P3181
P356
10.1006/JMBI.1997.1586
P407
P577
1998-03-27T00:00:00Z