Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases
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A DNA topoisomerase IB in Thaumarchaeota testifies for the presence of this enzyme in the last common ancestor of Archaea and EucaryaThe role of lysine 532 in the catalytic mechanism of human topoisomerase IStructure of the N-terminal fragment of topoisomerase V reveals a new family of topoisomerases.Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomicsThe interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53Atomic force microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in a cooperative fashion.Asymmetric DNA bending in the Cre-loxP site-specific recombination synapseArm-site binding by lambda -integrase: solution structure and functional characterization of its amino-terminal domainThe Order of Strand Exchanges in Cre-LoxP Recombination and its Basis Suggested by the Crystal Structure of a Cre-LoxP Holliday Junction ComplexThe role of the conserved Trp330 in Flp-mediated recombination. Functional and structural analysisModulation of the Active Complex Assembly and Turnover Rate by Protein−DNA Interactions in Cre−LoxP Recombination † , ‡A specificity switch in selected cre recombinase variants is mediated by macromolecular plasticity and waterInsights from the Structure of a Smallpox Virus Topoisomerase-DNA Transition State MimicRequirements for catalysis in the Cre recombinase active siteCrystal Structure of a Bacterial Topoisomerase IB in Complex with DNA Reveals a Secondary DNA Binding SiteStructure of Yeast Kinetochore Ndc10 DNA-binding Domain Reveals Unexpected Evolutionary Relationship to Tyrosine RecombinasesThe Carboxy-Terminal αN Helix of the Archaeal XerA Tyrosine Recombinase Is a Molecular Switch to Control Site-Specific RecombinationUnique subunit packing in mycobacterial nanoRNase leads to alternate substrate recognitions in DHH phosphodiesterasesIdentification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation.Topoisomerase V relaxes supercoiled DNA by a constrained swiveling mechanismChemical and traditional mutagenesis of vaccinia DNA topoisomerase provides insights to cleavage site recognition and transesterification chemistry.New peptide inhibitors of type IB topoisomerases: similarities and differences vis-a-vis inhibitors of tyrosine recombinases.Inhibition of Flp recombinase by the topoisomerase I-targeting drugs, camptothecin and NSC-314622.Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins.Reversible inhibitors of lambda integrase-mediated recombination efficiently trap Holliday junction intermediates and form the basis of a novel assay for junction resolution.Functional mapping of Cre recombinase by pentapeptide insertional mutagenesis.A functional type I topoisomerase from Pseudomonas aeruginosa.Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesteraseHomology-dependent interactions determine the order of strand exchange by IntDOT recombinase.Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality.DNA topoisomerase I in oncology: Dr Jekyll or Mr Hyde?Vaccinia topoisomerase and Cre recombinase catalyze direct ligation of activated DNA substrates containing a 3'-para-nitrophenyl phosphate ester.Wild-type Flp recombinase cleaves DNA in trans.A human topoisomerase I cleavage complex is recognized by an additional human topisomerase I molecule in vitro.Electrostatic suppression allows tyrosine site-specific recombination in the absence of a conserved catalytic arginineA poxvirus-like type IB topoisomerase family in bacteria.Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes.Free energy calculations reveal rotating-ratchet mechanism for DNA supercoil relaxation by topoisomerase IB and its inhibition.Structure of the Holliday junction intermediate in Cre-loxP site-specific recombination.Reversed DNA strand cleavage specificity in initiation of Cre-LoxP recombination induced by the His289Ala active-site substitution
P2860
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P2860
Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
name
Conservation of structure and ...... and site-specific recombinases
@ast
Conservation of structure and ...... and site-specific recombinases
@en
Conservation of structure and ...... and site-specific recombinases
@nl
type
label
Conservation of structure and ...... and site-specific recombinases
@ast
Conservation of structure and ...... and site-specific recombinases
@en
Conservation of structure and ...... and site-specific recombinases
@nl
prefLabel
Conservation of structure and ...... and site-specific recombinases
@ast
Conservation of structure and ...... and site-specific recombinases
@en
Conservation of structure and ...... and site-specific recombinases
@nl
P2093
P3181
P1433
P1476
Conservation of structure and ...... and site-specific recombinases
@en
P2093
P304
P3181
P356
10.1016/S0092-8674(00)81411-7
P407
P577
1998-03-20T00:00:00Z