The role of lysine 532 in the catalytic mechanism of human topoisomerase I
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An Interlocked Dimer of the Protelomerase TelK Distorts DNA Structure for the Formation of Hairpin TelomeresStructural and dynamical effects induced by the anticancer drug topotecan on the human topoisomerase I - DNA complexBinding of an Indenoisoquinoline to the topoisomerase-DNA complex induces reduction of linker mobility and strengthening of protein-DNA interactionChemical and traditional mutagenesis of vaccinia DNA topoisomerase provides insights to cleavage site recognition and transesterification chemistry.A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex.Mutational analysis of the preferential binding of human topoisomerase I to supercoiled DNA.Sulfonoquinovosyl diacylglyceride selectively targets acute lymphoblastic leukemia cells and exerts potent anti-leukemic effects in vivo.A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism.DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant.Pyridoxal 5'-phosphate inactivates DNA topoisomerase IB by modifying the lysine general acid.Role of the linker domain and the 203-214 N-terminal residues in the human topoisomerase I DNA complex dynamics.DNA sequence selectivity of human topoisomerase I-mediated DNA cleavage induced by camptothecin.Crystal structure of a bacterial type IB DNA topoisomerase reveals a preassembled active site in the absence of DNA.Topoisomerases as anticancer targets.
P2860
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P2860
The role of lysine 532 in the catalytic mechanism of human topoisomerase I
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2004 nî lūn-bûn
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2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
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2004年の論文
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2004年論文
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2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
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2004年论文
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name
The role of lysine 532 in the catalytic mechanism of human topoisomerase I
@ast
The role of lysine 532 in the catalytic mechanism of human topoisomerase I
@en
The role of lysine 532 in the catalytic mechanism of human topoisomerase I
@nl
type
label
The role of lysine 532 in the catalytic mechanism of human topoisomerase I
@ast
The role of lysine 532 in the catalytic mechanism of human topoisomerase I
@en
The role of lysine 532 in the catalytic mechanism of human topoisomerase I
@nl
prefLabel
The role of lysine 532 in the catalytic mechanism of human topoisomerase I
@ast
The role of lysine 532 in the catalytic mechanism of human topoisomerase I
@en
The role of lysine 532 in the catalytic mechanism of human topoisomerase I
@nl
P2093
P2860
P356
P1476
The role of lysine 532 in the catalytic mechanism of human topoisomerase I
@en
P2093
Heidrun Interthal
James J Champoux
Paulene M Quigley
Wim G J Hol
P2860
P304
P356
10.1074/JBC.M309959200
P407
P577
2004-01-23T00:00:00Z