A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. - Wikidata - awgldk - TriplyDB

A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

http://www.wikidata.org/entity/Q27852131

about

Wnt Signaling in Cancer Stem Cell Biology Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine Targeting the Wnt pathways for therapies Flavonoids and Wnt/β-catenin signaling: potential role in colorectal cancer therapies Wnt signaling pathway in non-small cell lung cancer Toggling a conformational switch in Wnt/β-catenin signaling: regulation of Axin phosphorylation. The phosphorylation state of Axin controls its scaffold function in two Wnt pathway protein complexes Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals.Open tubular lab-on-column/mass spectrometry for targeted proteomics of nanogram sample amounts CIViC database Structure-Based Design of 2-Aminopyridine Oxazolidinones as Potent and Selective Tankyrase Inhibitors Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy Mouse models of colorectal cancer as preclinical models Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1.New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets The regulation of β-catenin activity and function in cancer: therapeutic opportunities The Wnt/β-catenin pathway in human fibrotic-like diseases and its eligibility as a therapeutic target.Evidence for tankyrases as antineoplastic targets in lung cancer.The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer.Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.Can we safely target the WNT pathway?Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling.Wnt pathway activation by ADP-ribosylation.Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase.The ADP-ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis in Drosophila The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2 Angiomotin stabilization by tankyrase inhibitors antagonizes constitutive TEAD-dependent transcription and proliferation of human tumor cells with Hippo pathway core component mutations Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer.The novel tankyrase inhibitor (AZ1366) enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance.Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation.Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.Tankyrases as drug targets.Genomic insights into WNT/β-catenin signaling.Tankyrases: structure, function and therapeutic implications in cancer.Recent advances in the structure-based rational design of TNKSIs.

P2860

Q26746101-4D282AD9-8BCA-42F2-A87F-B29B1032CD48 Q26796673-D1110CBC-D3E6-4D99-B765-646CF4D88ADD Q26821978-E8CF357C-39EE-42C8-859F-90344787280D Q26825474-D3A124A8-E480-47F8-817C-C64937958080 Q26825936-56935BDD-C974-4CFD-8BE8-FB0DBC44D7B4 Q26829995-8CE1E052-5082-403D-AF61-D353E9D69F72 Q27305064-BB8D9785-36B7-4AC1-AC67-5BC7FCACA6C7 Q27312175-3CB26493-245D-4CCD-A380-C3503B3FB7A6 Q27612411-E1C4CD26-D9C9-4ED7-97FB-EC9428B23E83 Q27684184-414FED5B-2876-43B9-9D2B-813148770323 Q27684215-1893B896-A85A-4040-A5E8-50D3B62C4E83 Q28078129-8F3C0D2C-C49A-4EBF-B14A-5FA15203D6AD Q28081871-EC2AD60F-9A92-44BC-BD23-8D7289639CD6 Q28550473-F794892F-5139-4324-8B51-040F1DA916E3 Q33580323-9F7FF36A-30A1-44B5-8ABA-5B3C6618730E Q33731804-D9CE0063-4934-4E6E-AA55-7AA66B7FF4C1 Q33779745-DA306EDA-CE4F-49F9-9C69-609ED1A6258F Q34670501-4645A4D0-3821-4300-8513-0F90985BEA3C Q34690600-FDA5D85D-39D0-4984-8CC7-76A42EC8616F Q34880355-317DF9FB-0164-4D8D-82D9-29E5A93557D6 Q35560868-3A0D3CBC-1193-4A8A-9ECA-426463166137 Q35591995-BC8AFDF8-73CD-478C-ABC6-340C32995258 Q35869295-E2A61D7F-E551-4AB7-ACF4-9FF0621DF582 Q36361024-6FAA8219-8FE2-4A6B-BCBB-723DCEAEC05F Q36515479-83BC0FCC-F4F6-49E8-BB9C-165E55606890 Q36562360-1B4EDA05-93E6-4285-8467-83DD28F97856 Q36871744-2BFA01C8-F6A4-4EA6-B53B-48767EE8FCF5 Q36875618-7D882843-D837-4F1E-8DE0-0CB3E962A397 Q36921138-5CA0FFC5-4A6E-4E0E-BCE0-383023627478 Q37066468-331DD9C2-6E6F-48F0-9145-2118A02DD4E0 Q37301667-52D56AE9-9A29-4619-A9B4-7E0F6FC0D66A Q37304378-A36A7F38-9C8E-4650-AABD-EA6152EA85D0 Q37317534-B783B4AE-1439-4799-B62F-EDE2D6C9109F Q37395251-6888A04C-FA3E-4576-A9E5-6B50334EDDE9 Q37708736-3AD1DC84-270E-4EC8-BA68-E911E2738561 Q37712074-4B26CF8B-CE17-449C-8619-9D893CBA2C18 Q38104494-650BFC57-4201-4359-9F82-B527540930C8 Q38173593-8625D401-4E62-489D-BBFF-F8247BF78134 Q38224266-8E0209FC-0419-46E7-9F67-97D1EA7F5399 Q38248320-DC630E7E-4411-4B51-BB10-08B316479690

P2860

A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

http://www.wikidata.org/entity/Q27852131

description

2013 nî lūn-bûn

@nan

2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

A novel tankyrase small-molecu ...... riven colorectal tumor growth.

@ast

A novel tankyrase small-molecu ...... riven colorectal tumor growth.

@en

A novel tankyrase small-molecu ...... riven colorectal tumor growth.

@nl

type

label

A novel tankyrase small-molecu ...... riven colorectal tumor growth.

@ast

A novel tankyrase small-molecu ...... riven colorectal tumor growth.

@en

A novel tankyrase small-molecu ...... riven colorectal tumor growth.

@nl

prefLabel

A novel tankyrase small-molecu ...... riven colorectal tumor growth.

@ast

A novel tankyrase small-molecu ...... riven colorectal tumor growth.

@en

A novel tankyrase small-molecu ...... riven colorectal tumor growth.

@nl

P1433

Q27852131-2E126AAC-91AB-4768-8029-7C1E887BB11C

P1476

Q27852131-D050A7F6-22FD-4910-BA8D-09BB35666B5C

P2093

Q27852131-02D94C7B-F6EB-49B6-A1F0-B703D420528D

Q27852131-068F02D0-7767-43F4-AF2A-44BD989617CA

Q27852131-220545A6-F6B8-46DC-A2DB-F611D04477B8

Q27852131-2FFD1BB9-3FF7-4738-980D-CCE14D5BC081

Q27852131-371F554A-5661-4810-844D-F330F739DCE9

Q27852131-3CAF1C63-0B21-44F6-8400-7B4F84F605A2

Q27852131-4BBFB81A-F609-46A0-A71A-27288382018F

Q27852131-6182C865-06B5-413C-A4E0-1944ED750ABE

Q27852131-62732B8B-ACAA-4751-B3F4-2CA456DF33AA

Q27852131-87584AA2-C12B-4EFF-AA37-57BF79F8C35A

P304

Q27852131-4D8ADED5-9319-4D64-ADB7-EA19A42DA170

P31

Q27852131-F29578FB-B116-4A5F-B482-207FAB982280

P3181

Q27852131-AC965765-E138-4185-AF12-0941DD9ED856

P356

Q27852131-DF8F3CEB-7B02-46CC-91A0-89FBAB60294E

P407

Q27852131-76045D71-60DF-4BB9-A8E9-1EB7696FF396

P433

Q27852131-4FD8FF37-B831-4AD5-8B94-7EB30D0F5068

P478

Q27852131-1891BE6C-3E45-481E-9513-DDDEF656BAC1

P50

Q27852131-D9361493-BC58-41B1-99D8-9FD642449127

P577

Q27852131-32607153-1C6C-42B4-826B-6AF0A24BE33A

P698

Q27852131-4FFD5BDF-D3DD-4F97-B5A5-1149F045EDBE

P3181

P356

0008-5472.CAN-12-4562

P1433

Cancer Research

P1476

A novel tankyrase small-molecu ...... driven colorectal tumor growth

@en

P2093

Amy Sambrone

http://www.w3.org/2001/XMLSchema#string

Daniel D Holsworth

http://www.w3.org/2001/XMLSchema#string

Dolores Diaz

http://www.w3.org/2001/XMLSchema#string

Edna Choo

http://www.w3.org/2001/XMLSchema#string

Emily Chan

http://www.w3.org/2001/XMLSchema#string

Jason Boggs

http://www.w3.org/2001/XMLSchema#string

Jo Waaler

http://www.w3.org/2001/XMLSchema#string

Marinella Callow

http://www.w3.org/2001/XMLSchema#string

Melissa Schutten

http://www.w3.org/2001/XMLSchema#string

Mike Costa

http://www.w3.org/2001/XMLSchema#string

P304

3132-3144

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

1903966

http://www.w3.org/2001/XMLSchema#string

P356

10.1158/0008-5472.CAN-12-4562

http://www.w3.org/2001/XMLSchema#string

P407

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

73

http://www.w3.org/2001/XMLSchema#string

P50

P577

2013-03-28T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

23539443

http://www.w3.org/2001/XMLSchema#string