about
Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexinStructural evolution of the protein kinase-like superfamilyStructural and functional diversity of the microbial kinomeStructure of the Ire1 autophosphorylation complex and implications for the unfolded protein responseAnalysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinaseCrystal structure of the Golgi casein kinaseThe amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf.Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimersIdentification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinaseIdentification and characterization of SSTK, a serine/threonine protein kinase essential for male fertilityActivation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADMechanism of activation and inhibition of the HER4/ErbB4 kinaseStructural basis for the recognition of c-Src by its inactivator CskAutoinhibition of the insulin-like growth factor I receptor by the juxtamembrane regionThe evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activityAllosteric activation of the protein kinase PDK1 with low molecular weight compoundsLarge-scale structural analysis of the classical human protein tyrosine phosphatomeProtein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2CASK Functions as a Mg2+-independent neurexin kinase14-3-3 binding to the IGF-1 receptor is mediated by serine autophosphorylationPAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin.A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinibCentral role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cellsCell signaling by receptor tyrosine kinasesA sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylationHelicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substratesOn the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporineCrystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252aMolecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipBA conserved protonation-dependent switch controls drug binding in the Abl kinaseDelineation of Polypharmacology across the Human Structural Kinome Using a Functional Site Interaction Fingerprint ApproachDifferential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanismsRegulation and substrate specificity of the SR protein kinase Clk/StyStructural basis for the autoinhibition of focal adhesion kinaseHuman members of the eukaryotic protein kinase familyEvolution of CASK into a Mg2+-sensitive kinaseMediator kinase module and human tumorigenesis
P2860
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P2860
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The conformational plasticity of protein kinases
@ast
The conformational plasticity of protein kinases
@en
The conformational plasticity of protein kinases
@nl
type
label
The conformational plasticity of protein kinases
@ast
The conformational plasticity of protein kinases
@en
The conformational plasticity of protein kinases
@nl
prefLabel
The conformational plasticity of protein kinases
@ast
The conformational plasticity of protein kinases
@en
The conformational plasticity of protein kinases
@nl
P3181
P1433
P1476
The conformational plasticity of protein kinases
@en
P2093
Morgan Huse
P304
P3181
P356
10.1016/S0092-8674(02)00741-9
P407
P50
P577
2002-05-03T00:00:00Z