The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
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Dietary fats and prevention of type 2 diabetesIs there a fatty acid taste?Oleogustus: The Unique Taste of FatAccumulating evidence supports a taste component for free fatty acids in humansA novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolismLipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assayThe orphan receptor GPR55 is a novel cannabinoid receptorIncorporation of branched-chain fatty acid into cellular lipids and caspase-independent apoptosis in human breast cancer cell line, SKBR-3.Nutritional Signaling via Free Fatty Acid ReceptorsBrain Lipotoxicity of Phytanic Acid and Very Long-chain Fatty Acids. Harmful Cellular/Mitochondrial Activities in Refsum Disease and X-Linked AdrenoleukodystrophyStimulation of incretin secreting cellsMultiple Factors Related to the Secretion of Glucagon-Like Peptide-1Mechanisms of omega-3 polyunsaturated fatty acids in prostate cancer preventionRecent advances in gut nutrient chemosensingGPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.Gut chemosensing: implications for disease pathogenesisHomeostasis, inflammation, and disease susceptibilityInflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytesOmega-3 Fatty Acids and PPARgamma in CancerInternational Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cellsOleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db miceA Single Amino Acid Mutation (R104P) in the E/DRY Motif of GPR40 Impairs Receptor FunctionInhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose productionLinolenic acid provides multi-cellular protective effects after photothrombotic cerebral ischemia in ratsFree fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodentsGPR40 agonist ameliorates liver X receptor-induced lipid accumulation in liver by activating AMPK pathwayThe Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsVariants in the FFAR1 gene are associated with beta cell function.Novel translocation responses of cytosolic phospholipase A2alpha fluorescent proteins.Palmitate-induced beta-cell dysfunction is associated with excessive NO production and is reversed by thiazolidinedione-mediated inhibition of GPR40 transduction mechanisms.Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance.Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist.
P2860
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P2860
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The orphan G protein-coupled r ...... um and long chain fatty acids.
@ast
The orphan G protein-coupled r ...... um and long chain fatty acids.
@en
The orphan G protein-coupled r ...... um and long chain fatty acids.
@nl
type
label
The orphan G protein-coupled r ...... um and long chain fatty acids.
@ast
The orphan G protein-coupled r ...... um and long chain fatty acids.
@en
The orphan G protein-coupled r ...... um and long chain fatty acids.
@nl
altLabel
The orphan G protein-coupled r ...... ium and long chain fatty acids
@en
prefLabel
The orphan G protein-coupled r ...... um and long chain fatty acids.
@ast
The orphan G protein-coupled r ...... um and long chain fatty acids.
@en
The orphan G protein-coupled r ...... um and long chain fatty acids.
@nl
P2093
P921
P3181
P356
P1476
The orphan G protein-coupled r ...... um and long chain fatty acids.
@en
P2093
Celia P Briscoe
John L Andrews
Jon K Chambers
Michelle M Eilert
Mohammad Tadayyon
Nabil A Elshourbagy
Paul R Murdock
Philip G Szekeres
Shelagh Wilson
Usman Shabon
P304
P3181
P356
10.1074/JBC.M211495200
P407
P577
2003-03-28T00:00:00Z