Role of GPR40 in fatty acid action on the beta cell line INS-1E.
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High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875Pancreatic regulation of glucose homeostasisGuards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetesGPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cellsGPR40 agonist ameliorates liver X receptor-induced lipid accumulation in liver by activating AMPK pathwayDrug design for G-protein-coupled receptors by a ligand-based NMR method.Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist.Lipid receptors and islet function: therapeutic implications?Linoleic acid stimulates [Ca2+]i increase in rat pancreatic beta-cells through both membrane receptor- and intracellular metabolite-mediated pathways.Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of diabetes and improves beta cell preservation and function in male ZDF ratsThe expression of the beta cell-derived autoimmune ligand for the killer receptor nkp46 is attenuated in type 2 diabetes.Differential Gene Expression in GPR40-Overexpressing Pancreatic β-cells Treated with Linoleic Acid.CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients.Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 AgonistDifferential intracellular calcium influx, nitric oxide production, ICAM-1 and IL8 expression in primary bovine endothelial cells exposed to nonesterified fatty acidsGPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.Nutritional regulation of insulin secretion: implications for diabetes.Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases.The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin.Gustducin couples fatty acid receptors to GLP-1 release in colon.Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects.Fatty acid receptors as new therapeutic targets for diabetes.The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.Differential modulation of L-type calcium channel subunits by oleate.GPR40: good cop, bad cop?Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes.Fasiglifam as a new potential treatment option for patients with type 2 diabetes.GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit.Return of the glucoreceptor: Glucose activates the glucose-sensing receptor T1R3 and facilitates metabolism in pancreatic β-cells.Agonist-induced activation of human FFA1 receptor signals to extracellular signal-regulated kinase 1 and 2 through Gq- and Gi-coupled signaling cascades.Free fatty acid receptor agonists for the treatment of type 2 diabetes: drugs in preclinical to phase II clinical development.β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges.Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11GPR40-induced insulin secretion by the novel agonist TAK-875: first clinical findings in patients with type 2 diabetes.Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.
P2860
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P2860
Role of GPR40 in fatty acid action on the beta cell line INS-1E.
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Role of GPR40 in fatty acid action on the beta cell line INS-1E.
@ast
Role of GPR40 in fatty acid action on the beta cell line INS-1E.
@en
Role of GPR40 in fatty acid action on the beta cell line INS-1E.
@nl
type
label
Role of GPR40 in fatty acid action on the beta cell line INS-1E.
@ast
Role of GPR40 in fatty acid action on the beta cell line INS-1E.
@en
Role of GPR40 in fatty acid action on the beta cell line INS-1E.
@nl
altLabel
Role of GPR40 in fatty acid action on the beta cell line INS-1E
@en
prefLabel
Role of GPR40 in fatty acid action on the beta cell line INS-1E.
@ast
Role of GPR40 in fatty acid action on the beta cell line INS-1E.
@en
Role of GPR40 in fatty acid action on the beta cell line INS-1E.
@nl
P2093
P921
P3181
P1476
Role of GPR40 in fatty acid action on the beta cell line INS-1E.
@en
P2093
Hagit Shapiro
Israel Sekler
Michael D Walker
Michal Hershfinkel
Sigal Shachar
P304
P3181
P356
10.1016/J.BBRC.2005.07.042
P407
P577
2005-09-16T00:00:00Z