β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.
about
Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretionThe P21-activated kinase PAK4 is implicated in fatty-acid potentiation of insulin secretion downstream of free fatty acid receptor 1.Fatty acid and mineral receptors as drug targets for gastrointestinal disorders.The Role and Future of FFA1 as a Therapeutic Target.Invited review: nutrient-sensing receptors for free fatty acids and hydroxycarboxylic acids in farm animals.Key Questions for Translation of FFA Receptors: From Pharmacology to Medicines.Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges.G Protein-Coupled Receptor Signaling Through β-Arrestin-Dependent Mechanisms.Fasiglifam (TAK-875) has dual potentiating mechanisms via Gαq-GPR40/FFAR1 signaling branches on glucose-dependent insulin secretion.Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance.Biased signalling: from simple switches to allosteric microprocessors.Incretin-Based Therapies: Revisiting Their Mode of Action.20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1.Using Biosensors to Study Free Fatty Acid Receptor Pharmacology and Function.Ligands at Free Fatty Acid Receptor 1 (GPR40).Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism.Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment.
P2860
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P2860
β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.
@en
type
label
β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.
@en
prefLabel
β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.
@en
P2093
P2860
P356
P1476
β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.
@en
P2093
Arturo D Mancini
Caroline Tremblay
Gyslaine Bertrand
Julien Ghislain
Kevin Vivot
Éric Carpentier
P2860
P304
21131-21140
P356
10.1074/JBC.M115.644450
P407
P577
2015-07-08T00:00:00Z