A single immunoglobulin-like domain of the human neural cell adhesion molecule L1 supports adhesion by multiple vascular and platelet integrins
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Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGFInteractions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3The role of endocytosis in regulating L1-mediated adhesionMolecular cloning of a dendritic cell-associated transmembrane protein, DC-HIL, that promotes RGD-dependent adhesion of endothelial cells through recognition of heparan sulfate proteoglycansIntegrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry.PC12 cells utilize the homophilic binding site of L1 for cell-cell adhesion but L1-alphavbeta3 interaction for neurite outgrowth.RNA interference-mediated knockdown of CD49e (α5 integrin chain) in human thymic epithelial cells modulates the expression of multiple genes and decreases thymocyte adhesionL1-mediated branching is regulated by two ezrin-radixin-moesin (ERM)-binding sites, the RSLE region and a novel juxtamembrane ERM-binding region.Inside-out regulation of L1 conformation, integrin binding, proteolysis, and concomitant cell migration.Involvement of integrin alpha(v)beta(3) and cell adhesion molecule L1 in transendothelial migration of melanoma cells.Serpins promote cancer cell survival and vascular co-option in brain metastasisTargeting L1 cell adhesion molecule expression using liposome-encapsulated siRNA suppresses prostate cancer bone metastasis and growth.L1 cell adhesion molecule as a potential therapeutic target in murine models of endometriosis using a monoclonal antibody approach.Contact-dependent signaling during the late events of platelet activation.A role for the alphavbeta3 integrin in the transmigration of monocytes.Transcytosis of NgCAM in epithelial cells reflects differential signal recognition on the endocytic and secretory pathways.Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitmentEctodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins.The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells.Molecular interplay between endostatin, integrins, and heparan sulfate.Stimulation of glioma cell motility by expression, proteolysis, and release of the L1 neural cell recognition molecule.The Pleiotropic Role of L1CAM in Tumor VasculatureL1CAM: a major driver for tumor cell invasion and motility.Overcoming barriers and thresholds - signaling of oligomeric Aβ through the prion protein to Fyn.Initial afferent lymphatic vessels controlling outbound leukocyte traffic from skin to lymph nodes.CHL1, ITGB3 and SLC6A4 gene expression and antidepressant drug response: results from the Munich Antidepressant Response Signature (MARS) study.A point mutation in the extracellular domain of L1 blocks its capacity to confer metastasis in colon cancer cells via CD10.Influence of L1-CAM expression of breast cancer cells on adhesion to endothelial cells.In Vivo and protease-activated receptor-1-mediated platelet activation in patients presenting for cardiac catheterization.Close homolog of L1 is an enhancer of integrin-mediated cell migration.The third fibronectin type III repeat is required for L1 to serve as an optimal substratum for neurite extension.The role of alphav integrins during angiogenesis.Oriented, multimeric biointerfaces of the L1 cell adhesion molecule: an approach to enhance neuronal and neural stem cell functions on 2-D and 3-D polymer substrates.Imatinib upregulates compensatory integrin signaling in a mouse model of gastrointestinal stromal tumor and is more effective when combined with dasatinib.Pharmacology of cell adhesion molecules of the nervous system.An integrin-tetraspanin interaction required for cellular innate immune responses of an insect, Manduca sexta.Regulation of cell adhesion by polysialic acid. Effects on cadherin, immunoglobulin cell adhesion molecule, and integrin function and independence from neural cell adhesion molecule binding or signaling activity.Integrin and neurocan binding to L1 involves distinct Ig domains.Cell Guidance by 3D-Gradients in Hydrogel Matrices: Importance for Biomedical Applications.
P2860
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P2860
A single immunoglobulin-like domain of the human neural cell adhesion molecule L1 supports adhesion by multiple vascular and platelet integrins
description
1997 nî lūn-bûn
@nan
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
A single immunoglobulin-like d ...... ascular and platelet integrins
@ast
A single immunoglobulin-like d ...... ascular and platelet integrins
@en
A single immunoglobulin-like d ...... scular and platelet integrins.
@nl
type
label
A single immunoglobulin-like d ...... ascular and platelet integrins
@ast
A single immunoglobulin-like d ...... ascular and platelet integrins
@en
A single immunoglobulin-like d ...... scular and platelet integrins.
@nl
altLabel
A single immunoglobulin-like d ...... ascular and platelet integrins
@en
prefLabel
A single immunoglobulin-like d ...... ascular and platelet integrins
@ast
A single immunoglobulin-like d ...... ascular and platelet integrins
@en
A single immunoglobulin-like d ...... scular and platelet integrins.
@nl
P2093
P2860
P356
P1476
A single immunoglobulin-like d ...... ascular and platelet integrins
@en
P2093
A M Montgomery
B Felding-Habermann
D A Cheresh
M H Ginsberg
P C Brooks
S Silletti
T E O'Toole
P2860
P304
P356
10.1083/JCB.139.6.1567
P407
P577
1997-12-15T00:00:00Z