The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.
about
Caenorhabditis elegans cyclin B3 is required for multiple mitotic processes including alleviation of a spindle checkpoint-dependent block in anaphase chromosome segregationTripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachmentsGenome stability is ensured by temporal control of kinetochore-microtubule dynamicsKinetochore-microtubule interactions: steps towards bi-orientationShugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeresThe Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint SignalingThe Renaissance or the cuckoo clockThe current view for the silencing of the spindle assembly checkpointReconstituting the kinetochore–microtubule interface: what, why, and howDirect monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activationThe molecular architecture of the Dam1 kinetochore complex is defined by cross-linking based structural modelling.Loss of function of the Cik1/Kar3 motor complex results in chromosomes with syntelic attachment that are sensed by the tension checkpointIpl1/Aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome integrity during meiosisKinetochore biorientation in Saccharomyces cerevisiae requires a tightly folded conformation of the Ndc80 complex.Mps1 phosphorylation of Dam1 couples kinetochores to microtubule plus ends at metaphase.DNA topoisomerase II is a determinant of the tensile properties of yeast centromeric chromatin and the tension checkpointThe budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7).Bub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis.Ypi1, a positive regulator of nuclear protein phosphatase type 1 activity in Saccharomyces cerevisiae.Kinetochore orientation during meiosis is controlled by Aurora B and the monopolin complex.Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B.Efficient chromosome biorientation and the tension checkpoint in Saccharomyces cerevisiae both require Bir1.A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint.Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores.Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunitUbiquitin and SUMO systems in the regulation of mitotic checkpointsPhosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshinKinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpointConnecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.Perturbation of Incenp function impedes anaphase chromatid movements and chromosomal passenger protein flux at centromeresAurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly.DNA damage activates the SAC in an ATM/ATR-dependent manner, independently of the kinetochore.Tension applied through the Dam1 complex promotes microtubule elongation providing a direct mechanism for length control in mitosisPhosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation.Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosisTemporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis.The NDC80 complex proteins Nuf2 and Hec1 make distinct contributions to kinetochore-microtubule attachment in mitosisThe Ndc80 kinetochore complex directly modulates microtubule dynamics.Survivin safeguards chromosome numbers and protects from aneuploidy independently from p53Kinetochores require oligomerization of Dam1 complex to maintain microtubule attachments against tension and promote biorientation.
P2860
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P2860
The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.
description
2006 nî lūn-bûn
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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
The Ipl1-Aurora protein kinase ...... ating unattached kinetochores.
@ast
The Ipl1-Aurora protein kinase ...... ating unattached kinetochores.
@en
The Ipl1-Aurora protein kinase ...... ating unattached kinetochores.
@nl
type
label
The Ipl1-Aurora protein kinase ...... ating unattached kinetochores.
@ast
The Ipl1-Aurora protein kinase ...... ating unattached kinetochores.
@en
The Ipl1-Aurora protein kinase ...... ating unattached kinetochores.
@nl
prefLabel
The Ipl1-Aurora protein kinase ...... ating unattached kinetochores.
@ast
The Ipl1-Aurora protein kinase ...... ating unattached kinetochores.
@en
The Ipl1-Aurora protein kinase ...... ating unattached kinetochores.
@nl
P2093
P2860
P3181
P356
P1433
P1476
The Ipl1-Aurora protein kinase ...... ating unattached kinetochores.
@en
P2093
Benjamin A Pinsky
Charles Kung
Kevan M Shokat
Sue Biggins
P2860
P2888
P3181
P356
10.1038/NCB1341
P407
P577
2006-01-01T00:00:00Z
P5875
P6179
1036049177