Yeast telomerase subunit Est1p has guanine quadruplex-promoting activity that is required for telomere elongation.
about
Functional analysis of the single Est1/Ebs1 homologue in Kluyveromyces lactis reveals roles in both telomere maintenance and rapamycin resistanceTelomeres-structure, function, and regulationModulation of yeast telomerase activity by Cdc13 and Est1 in vitro.Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length.Characterization of the intramolecular G-quadruplex promoting activity of Est1.The Saccharomyces cerevisiae telomerase subunit Est3 binds telomeres in a cell cycle- and Est1-dependent manner and interacts directly with Est1 in vitroFluorescence-based duplex-quadruplex competition test to screen for telomerase RNA quadruplex ligandsSingle molecule studies of physiologically relevant telomeric tails reveal POT1 mechanism for promoting G-quadruplex unfolding.The principal role of Ku in telomere length maintenance is promotion of Est1 association with telomeresG-quadruplex nucleic acids and human diseaseTelomeric repeat mutagenicity in human somatic cells is modulated by repeat orientation and G-quadruplex stability.Telomere-regulating genes and the telomere interactome in familial cancers.Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiaeG-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase.The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro.Telomerase regulatory subunit Est3 in two Candida species physically interacts with the TEN domain of TERT and telomeric DNA.Telomeric G-quadruplexes are a substrate and site of localization for human telomeraseIntramolecular telomeric G-quadruplexes dramatically inhibit DNA synthesis by replicative and translesion polymerases, revealing their potential to lead to genetic change.Structural identity of telomeric complexes.Cdc13 at a crossroads of telomerase actionCoexistence of G-quadruplex and duplex domains within the secondary structure of 31-mer DNA thrombin-binding aptamer.Seven essential questions on G-quadruplexes.Reversible Immortalization Enables Seamless Transdifferentiation of Primary Fibroblasts into Other Lineage Cells.A telomerase-associated RecQ protein-like helicase resolves telomeric G-quadruplex structures during replicationEst1 protects telomeres and inhibits subtelomeric y'-element recombination.TTAGG-repeat telomeres and characterization of telomerase in the beet armyworm, Spodoptera exigua (Lepidoptera: Noctuidae).Using Separation-of-Function Mutagenesis To Define the Full Spectrum of Activities Performed by the Est1 Telomerase Subunit in Vivo.
P2860
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P2860
Yeast telomerase subunit Est1p has guanine quadruplex-promoting activity that is required for telomere elongation.
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Yeast telomerase subunit Est1p ...... uired for telomere elongation.
@ast
Yeast telomerase subunit Est1p ...... uired for telomere elongation.
@en
Yeast telomerase subunit Est1p ...... uired for telomere elongation.
@nl
type
label
Yeast telomerase subunit Est1p ...... uired for telomere elongation.
@ast
Yeast telomerase subunit Est1p ...... uired for telomere elongation.
@en
Yeast telomerase subunit Est1p ...... uired for telomere elongation.
@nl
prefLabel
Yeast telomerase subunit Est1p ...... uired for telomere elongation.
@ast
Yeast telomerase subunit Est1p ...... uired for telomere elongation.
@en
Yeast telomerase subunit Est1p ...... uired for telomere elongation.
@nl
P2093
P2860
P3181
P356
P1476
Yeast telomerase subunit Est1p ...... uired for telomere elongation.
@en
P2093
Jianping Ding
Jianyong Wang
Jin-Qiu Zhou
Ming-Liang Zhang
Qian-Jin Li
Xia-Jing Tong
Xiao-Hong Fu
Xin-Hua Liao
P2860
P2888
P3181
P356
10.1038/NSMB.1760
P407
P577
2010-02-01T00:00:00Z
P6179
1050011975