G-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase.
about
Finding the end: recruitment of telomerase to telomeresTelomere and Telomerase Therapeutics in CancerG-quadruplexes and helicasesTelomeres-structure, function, and regulationIFI16 Preferentially Binds to DNA with Quadruplex Structure and Enhances DNA Quadruplex FormationTelomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cellsChiral metallohelices enantioselectively target hybrid human telomeric G-quadruplex DNA.RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATPG-quadruplexes in viruses: function and potential therapeutic applications.Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structuresTelomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteinsFanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction.Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for Tight and Complete Binding.POT1-TPP1 Binding and Unfolding of Telomere DNA Discriminates against Structural Polymorphism.Competition between stacked and hydrogen bonded structures of cytosine aggregates.Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans.G-ruption: the third international meeting on G-quadruplex and G-assembly.Guanine-rich sequences inhibit proofreading DNA polymerases.Clinical implications of antitelomeric drugs with respect to the nontelomeric functions of telomerase in cancerBioinformatic analysis reveals an evolutional selection for DNA:RNA hybrid G-quadruplex structures as putative transcription regulatory elements in warm-blooded animalsEffect of sequence and metal ions on UVB-induced anti cyclobutane pyrimidine dimer formation in human telomeric DNA sequences.The yin and yang of repair mechanisms in DNA structure-induced genetic instability.G-quadruplexes as potential therapeutic targets for embryonal tumors.Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instabilityTERRA mimicking ssRNAs prevail over the DNA substrate for telomerase in vitro due to interactions with the alternative binding site.Beyond Telomerase: Telomere Instability as a Novel Target for Cancer Therapy.Effects of Replication and Transcription on DNA Structure-Related Genetic InstabilityRNA G-quadruplexes and their potential regulatory roles in translation.Myricetin arrests human telomeric G-quadruplex structure: a new mechanistic approach as an anticancer agent.Heme activation by DNA: isoguanine pentaplexes, but not quadruplexes, bind heme and enhance its oxidative activity.Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand.A telomerase-associated RecQ protein-like helicase resolves telomeric G-quadruplex structures during replicationTranscription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex.Effects of monovalent cations on folding kinetics of G-quadruplexesAccelerated aging during chronic oxidative stress: a role for PARP-1.
P2860
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P2860
G-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
G-quadruplex formation at the ...... ase and unwinding by helicase.
@ast
G-quadruplex formation at the ...... ase and unwinding by helicase.
@en
type
label
G-quadruplex formation at the ...... ase and unwinding by helicase.
@ast
G-quadruplex formation at the ...... ase and unwinding by helicase.
@en
prefLabel
G-quadruplex formation at the ...... ase and unwinding by helicase.
@ast
G-quadruplex formation at the ...... ase and unwinding by helicase.
@en
P2093
P2860
P356
P1476
G-quadruplex formation at the ...... ase and unwinding by helicase.
@en
P2093
Chang-yue Chen
Jia-quan Liu
Ke-wei Zheng
Yu-Hua Hao
P2860
P304
P356
10.1093/NAR/GKR164
P407
P577
2011-03-25T00:00:00Z