Identification and characterization of yUAP/Sub2p, a yeast homolog of the essential human pre-mRNA splicing factor hUAP56
about
TREX is a conserved complex coupling transcription with messenger RNA exportGrowth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteinsU2 small nuclear ribonucleoprotein particle (snRNP) auxiliary factor of 65 kDa, U2AF65, can promote U1 snRNP recruitment to 5' splice sitesp68 RNA helicase is an essential human splicing factor that acts at the U1 snRNA-5' splice site duplex.Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway.Functional roles of DExD/H-box RNA helicases in Pre-mRNA splicingStable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1pEvidence for a role of Sky1p-mediated phosphorylation in 3' splice site recognition involving both Prp8 and Prp17/Slu4.Leo1 subunit of the yeast paf1 complex binds RNA and contributes to complex recruitment.Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activationCotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex.Interactions between mRNA export commitment, 3'-end quality control, and nuclear degradationSplicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p.Comprehensive mutational analysis of yeast DEXD/H box RNA helicases required for small ribosomal subunit synthesis.A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complexPre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and AlyThe ATP requirement for U2 snRNP addition is linked to the pre-mRNA region 5' to the branch site.Arabidopsis DEAD-box RNA helicase UAP56 interacts with both RNA and DNA as well as with mRNA export factors5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly.Crystal structure of the human ATP-dependent splicing and export factor UAP56.ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA.Invariant U2 snRNA nucleotides form a stem loop to recognize the intron early in splicing.Homolog of BRCA2-interacting Dss1p and Uap56p link Mlo3p and Rae1p for mRNA export in fission yeastAn essential nuclear protein in trypanosomes is a component of mRNA transcription/export pathway.Comprehensive mutational analysis of yeast DEXD/H box RNA helicases involved in large ribosomal subunit biogenesisExpression of the essential mRNA export factor Yra1p is autoregulated by a splicing-dependent mechanism.UAP56 levels affect viability and mRNA export in Caenorhabditis elegans.Role of transcription in plasmid maintenance in the hpr1Delta mutant of Saccharomyces cerevisiaeDeletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase.Structural basis for recognition of intron branchpoint RNA by yeast Msl5 and selective effects of interfacial mutations on splicing of yeast pre-mRNAs.Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.Mutation of the arginine finger in the active site of Escherichia coli DbpA abolishes ATPase and helicase activity and confers a dominant slow growth phenotypeRemodeling of ribonucleoprotein complexes with DExH/D RNA helicases.mRNA journey to the cytoplasm: attire required.A new regulatory pathway of mRNA export by an F-box protein, Mdm30Probing interactions between the U2 small nuclear ribonucleoprotein and the DEAD-box protein, Prp5.Viral factors reveal a role for REF/Aly in nuclear RNA stability.High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability.Intron status and 3'-end formation control cotranscriptional export of mRNA.
P2860
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P2860
Identification and characterization of yUAP/Sub2p, a yeast homolog of the essential human pre-mRNA splicing factor hUAP56
description
2001 nî lūn-bûn
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2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Identification and characteriz ...... re-mRNA splicing factor hUAP56
@ast
Identification and characteriz ...... re-mRNA splicing factor hUAP56
@en
Identification and characteriz ...... e-mRNA splicing factor hUAP56.
@nl
type
label
Identification and characteriz ...... re-mRNA splicing factor hUAP56
@ast
Identification and characteriz ...... re-mRNA splicing factor hUAP56
@en
Identification and characteriz ...... e-mRNA splicing factor hUAP56.
@nl
prefLabel
Identification and characteriz ...... re-mRNA splicing factor hUAP56
@ast
Identification and characteriz ...... re-mRNA splicing factor hUAP56
@en
Identification and characteriz ...... e-mRNA splicing factor hUAP56.
@nl
P2860
P356
P1433
P1476
Identification and characteriz ...... re-mRNA splicing factor hUAP56
@en
P2093
P2860
P356
10.1101/GAD.851701
P407
P577
2001-01-01T00:00:00Z