High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability.
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TREX is a conserved complex coupling transcription with messenger RNA exportThe yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability.Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1pNab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism.Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutantsAn hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination.Interactions between mRNA export commitment, 3'-end quality control, and nuclear degradationThe THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.Coupling of termination, 3' processing, and mRNA exportRole of transcription in plasmid maintenance in the hpr1Delta mutant of Saccharomyces cerevisiaeThe connection between transcription and genomic instability.Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse.An early function during transcription for the yeast mRNA export factor Dbp5p/Rat8p suggested by its genetic and physical interactions with transcription factor IIH componentsGenes with internal repeats require the THO complex for transcriptionHYPER RECOMBINATION1 of the THO/TREX complex plays a role in controlling transcription of the REVERSION-TO-ETHYLENE SENSITIVITY1 gene in Arabidopsis.Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1pThe RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability.Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouseMutational analysis of the yeast RNA helicase Sub2p reveals conserved domains required for growth, mRNA export, and genomic stability.Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase.Transcription and recombination: when RNA meets DNA.Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae.Defective nucleotide excision repair in yeast hpr1 and tho2 mutants.Biochemical analysis of TREX complex recruitment to intronless and intron-containing yeast genes.The Npl3 hnRNP prevents R-loop-mediated transcription-replication conflicts and genome instabilityR-loops do not accumulate in transcription-defective hpr1-101 mutants: implications for the functional role of THO/TREX.Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability.Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation.
P2860
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P2860
High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
High-copy-number expression of ...... -mediated genomic instability.
@en
High-copy-number expression of ...... -mediated genomic instability.
@nl
type
label
High-copy-number expression of ...... -mediated genomic instability.
@en
High-copy-number expression of ...... -mediated genomic instability.
@nl
prefLabel
High-copy-number expression of ...... -mediated genomic instability.
@en
High-copy-number expression of ...... -mediated genomic instability.
@nl
P2860
P1476
High-copy-number expression of ...... -mediated genomic instability.
@en
P2093
P2860
P304
P356
10.1128/MCB.21.16.5459-5470.2001
P407
P577
2001-08-01T00:00:00Z