Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae
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CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase.miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOTAnti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylaseConservation of the deadenylase activity of proteins of the Caf1 family in humanIdentification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding proteinUNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinantRepression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complexC2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complexMammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylationThe BTG2 protein is a general activator of mRNA deadenylationUpf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decayPoly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding proteinThe Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferationStructural basis for the antiproliferative activity of the Tob-hCaf1 complexThe Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescenceAn unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodiesNot1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolinThe role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viabilityHuman Ccr4-Not complexes contain variable deadenylase subunitsMechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylasesA multiplicity of coactivators is required by Gcn4p at individual promoters in vivoDNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex.The organization and regulation of mRNA-protein complexesCcr4-Not complex: the control freak of eukaryotic cellsMechanisms of deadenylation-dependent decayRecombinant messenger RNA technology and its application in cancer immunotherapy, transcript replacement therapies, pluripotent stem cell induction, and beyondProteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systemsHeterogeneity and complexity within the nuclease module of the Ccr4-Not complexThe Not4 RING E3 Ligase: A Relevant Player in Cotranslational Quality ControlConceptual modeling of mRNA decay provokes new hypothesesX-ray structure and activity of the yeast Pop2 protein: a nuclease subunit of the mRNA deadenylase complexThe 1.4-A crystal structure of the S. pombe Pop2p deadenylase subunit unveils the configuration of an active enzymeThe activity and selectivity of fission yeast Pop2p are affected by a high affinity for Zn2+ and Mn2+ in the active siteCrystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificityThe structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinaseNutrients and the Pkh1/2 and Pkc1 protein kinases control mRNA decay and P-body assembly in yeastThe yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex.The Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation--via a newly identified Glc7/Bud14 type I protein phosphatase module--and TFIID promoter distribution.PUF proteins bind Pop2p to regulate messenger RNAs.Single-molecule mRNA decay measurements reveal promoter- regulated mRNA stability in yeast
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P2860
Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae
description
2002 nî lūn-bûn
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2002 թվականի մարտին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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name
Ccr4p is the catalytic subunit ...... ex in Saccharomyces cerevisiae
@ast
Ccr4p is the catalytic subunit ...... ex in Saccharomyces cerevisiae
@en
Ccr4p is the catalytic subunit ...... x in Saccharomyces cerevisiae.
@nl
type
label
Ccr4p is the catalytic subunit ...... ex in Saccharomyces cerevisiae
@ast
Ccr4p is the catalytic subunit ...... ex in Saccharomyces cerevisiae
@en
Ccr4p is the catalytic subunit ...... x in Saccharomyces cerevisiae.
@nl
prefLabel
Ccr4p is the catalytic subunit ...... ex in Saccharomyces cerevisiae
@ast
Ccr4p is the catalytic subunit ...... ex in Saccharomyces cerevisiae
@en
Ccr4p is the catalytic subunit ...... x in Saccharomyces cerevisiae.
@nl
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Ccr4p is the catalytic subunit ...... ex in Saccharomyces cerevisiae
@en
P2093
Denise Muhlrad
Marco A Valencia-Sanchez
Morgan Tucker
Robin R Staples
Roy Parker
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P304
P3181
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10.1093/EMBOJ/21.6.1427
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2002-03-15T00:00:00Z