about
High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationshipsCharacterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenaseMechanism and substrate recognition of human holo ACP synthaseStructural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activityInterplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma proteinStructural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2AThree-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20betAldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stressThe SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiativeStructural genomics of histone tail recognitionProtein production and purificationTowards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implicationsStructural Basis for Different Specificities of Acyltransferases Associated with the Human Cytosolic and Mitochondrial Fatty Acid Synthases8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase InhibitorsCrystal structures of histone demethylase JMJD2A reveal basis for substrate specificityInhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylasesTargeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosisCrystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencingCrystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylaseSelective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic ApproachesCrystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor designStructural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachmentCrystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6Structures of the Human GTPase MMAA and Vitamin B 12 -dependent Methylmalonyl-CoA Mutase and Insight into Their Complex FormationThe crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activityMolecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium ParasitesQuantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase InhibitorsStructure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDSCrystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimmingStructure and Mechanism of Human UDP-glucose 6-DehydrogenaseA selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage responseStructural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase FamilyStructural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme IntermediatesConformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesisInsight into S -adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunitsLinking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylasesCrystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor developmentCrystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing MutationsStructure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Udo Oppermann
@ast
Udo Oppermann
@en
Udo Oppermann
@es
Udo Oppermann
@sl
type
label
Udo Oppermann
@ast
Udo Oppermann
@en
Udo Oppermann
@es
Udo Oppermann
@sl
prefLabel
Udo Oppermann
@ast
Udo Oppermann
@en
Udo Oppermann
@es
Udo Oppermann
@sl