Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors - Wikidata - awgldk - TriplyDB

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

http://www.wikidata.org/entity/Q27666155

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PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair Cold and Hot Extremozymes: Industrial Relevance and Current Trends Epigenomics of leukemia: from mechanisms to therapeutic applications Epigenetic regulation by histone demethylases in hypoxia High-throughput screening to identify inhibitors of lysine demethylases The role of histone demethylases in cancer therapy Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases Potent inhibition of dinuclear zinc(II) peptidase, an aminopeptidase from Aeromonas proteolytica, by 8-quinolinol derivatives: inhibitor design based on Zn2+ fluorophores, kinetic, and X-ray crystallographic study A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening Substituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylases Structural analysis of human KDM5B guides histone demethylase inhibitor development Cell-based assays to support the profiling of small molecules with histone methyltransferase and demethylase modulatory activity Epigenome-based personalized medicine in human cancer Inhibition of 2-oxoglutarate dependent oxygenases Open access target validation is a more efficient way to accelerate drug discovery Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's Disease Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens.The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.A photoreactive small-molecule probe for 2-oxoglutarate oxygenases.Methods for Activity Analysis of the Proteins that Regulate Histone Methylation Configuration of a high-content imaging platform for hit identification and pharmacological assessment of JMJD3 demethylase enzyme inhibitors.Perspectives on the discovery of small-molecule modulators for epigenetic processes.Identification of catechols as histone-lysine demethylase inhibitors.Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.Targeting histone lysine demethylases - progress, challenges, and the future KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor.Identification of small molecule modulators of gene transcription with anticancer activity.Small-molecular modulators of cancer-associated epigenetic mechanisms.A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth.A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms.The Evolution of MALDI-TOF Mass Spectrometry toward Ultra-High-Throughput Screening: 1536-Well Format and Beyond.Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential.A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1 Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.

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Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

http://www.wikidata.org/entity/Q27666155

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

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name

Quantitative High-Throughput S ...... Histone Demethylase Inhibitors

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Quantitative High-Throughput S ...... Histone Demethylase Inhibitors

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Quantitative High-Throughput S ...... Histone Demethylase Inhibitors

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Quantitative High-Throughput S ...... Histone Demethylase Inhibitors

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Quantitative High-Throughput S ...... Histone Demethylase Inhibitors

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Quantitative High-Throughput S ...... Histone Demethylase Inhibitors

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Quantitative High-Throughput S ...... Histone Demethylase Inhibitors

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Quantitative High-Throughput S ...... Histone Demethylase Inhibitors

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Quantitative High-Throughput S ...... Histone Demethylase Inhibitors

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Amy M Quinn

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David J Maloney

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Ganesha Rai

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Masaaki Sakurai

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Oliver N F King

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Paul Beswick

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Robert J Klose

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Stanley S Ng

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Tom D Heightman

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Xuan Shirley Li

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P2860

Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation.

Compound Management for Quantitative High-Throughput Screening

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase

Evidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)

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e15535

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10.1371/JOURNAL.PONE.0015535

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11

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5

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Christopher J. Schofield

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2010-11-23T00:00:00Z

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49651910

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21124847

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High-throughput screening

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2990756

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