A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformation
about
Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cellsThe human SNARE protein Ykt6 mediates its own palmitoylation at C-terminal cysteine residuesMultiple sequence elements facilitate Chp Rho GTPase subcellular location, membrane association, and transforming activityHuntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferaseRas-induced cellular events (review)Structure and function of the C-terminal hypervariable region of K-Ras4B in plasma membrane targetting and transformationThe membrane binding domains of prostaglandin endoperoxide H synthases 1 and 2. Peptide mapping and mutational analysis.Discovery and characterization of inhibitors of human palmitoyl acyltransferases.Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway.In vitro and cellular assays for palmitoyl acyltransferases using fluorescent lipidated peptidesRole of Ras/Raf/MEK/ERK signaling in physiological hematopoiesis and leukemia development.Ras palmitoylation is necessary for N-Ras activation and signal propagation in growth factor signalling.H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway.Carboxyl methylation of Ras regulates membrane targeting and effector engagement.H-Ras does not need COP I- or COP II-dependent vesicular transport to reach the plasma membrane.Disrupting the transforming activity of shrimp ras(Q(61)K) by deleting the CAAX box at the C-terminus.Phospholipase D activation by norepinephrine is mediated by 12(s)-, 15(s)-, and 20-hydroxyeicosatetraenoic acids generated by stimulation of cytosolic phospholipase a2. tyrosine phosphorylation of phospholipase d2 in response to norepinephrine.Physicochemical sequence characteristics that influence S-palmitoylation propensity.Dual lipid modification of Arabidopsis Ggamma-subunits is required for efficient plasma membrane targeting.Mutation of Ha-Ras C Terminus Changes Effector Pathway Utilization
P2860
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P2860
A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformation
description
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im Januar 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/01/15)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/01/15)
@nl
наукова стаття, опублікована в січні 1999
@uk
name
A non-farnesylated Ha-Ras prot ...... erentiation and transformation
@ast
A non-farnesylated Ha-Ras prot ...... erentiation and transformation
@en
A non-farnesylated Ha-Ras prot ...... erentiation and transformation
@nl
type
label
A non-farnesylated Ha-Ras prot ...... erentiation and transformation
@ast
A non-farnesylated Ha-Ras prot ...... erentiation and transformation
@en
A non-farnesylated Ha-Ras prot ...... erentiation and transformation
@nl
prefLabel
A non-farnesylated Ha-Ras prot ...... erentiation and transformation
@ast
A non-farnesylated Ha-Ras prot ...... erentiation and transformation
@en
A non-farnesylated Ha-Ras prot ...... erentiation and transformation
@nl
P2093
P2860
P356
P1476
A non-farnesylated Ha-Ras prot ...... erentiation and transformation
@en
P2093
P2860
P304
P356
10.1074/JBC.274.3.1423
P407
P50
P577
1999-01-01T00:00:00Z