Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
about
Crystal structure of a human GABAA receptorEthanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine ReceptorsZinc-dependent modulation of α2- and α3-glycine receptor subunits by ethanol.Molecular sites for the positive allosteric modulation of glycine receptors by endocannabinoidsDifferentiated human midbrain-derived neural progenitor cells express excitatory strychnine-sensitive glycine receptors containing α2β subunitsVoltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic AcidEthanol effects on glycinergic transmission: From molecular pharmacology to behavior responsesMurine startle mutant Nmf11 affects the structural stability of the glycine receptor and increases deactivation.Tonic zinc inhibits spontaneous firing in dorsal cochlear nucleus principal neurons by enhancing glycinergic neurotransmission.AMPA receptor inhibition by synaptically released zincMolecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation.Mutation of a zinc-binding residue in the glycine receptor α1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivoZinc enhances ethanol modulation of the alpha1 glycine receptor.Pulsed electron spin resonance resolves the coordination site of Cu²(+) ions in α1-glycine receptorDisulphide trapping of the GABA(A) receptor reveals the importance of the coupling interface in the action of benzodiazepines.Zinc modulation of glycine receptorsIdentification and characterization of heptapeptide modulators of the glycine receptorInhibitory glycine receptors: an update.Modulating inhibitory ligand-gated ion channels.Glycine receptors: recent insights into their structural organization and functional diversity.Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist.Functional modulation of glycine receptors by the alkaloid gelsemine.Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia.The Free Zinc Concentration in the Synaptic Cleft of Artificial Glycinergic Synapses Rises to At least 1 μMNon-agonist-binding subunit interfaces confer distinct functional signatures to the alternate stoichiometries of the alpha4beta2 nicotinic receptor: an alpha4-alpha4 interface is required for Zn2+ potentiation.Physiological concentrations of zinc reduce taurine-activated GlyR responses to drugs of abuse.The GLRA1 missense mutation W170S associates lack of Zn2+ potentiation with human hyperekplexia.Contaminating levels of zinc found in commonly-used labware and buffers affect glycine receptor currents.Review: Zinc's functional significance in the vertebrate retinaStructure and Pharmacologic Modulation of Inhibitory Glycine Receptors.Mapping a molecular link between allosteric inhibition and activation of the glycine receptor.The desensitization gate of inhibitory Cys-loop receptors.Single-channel study of the spasmodic mutation alpha1A52S in recombinant rat glycine receptors.General anesthetics have additive actions on three ligand gated ion channels.Ethanol enhances taurine-activated glycine receptor function.Zinc as a Neuromodulator in the Central Nervous System with a Focus on the Olfactory Bulb.Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators.Interactions between Zinc and Allosteric Modulators of the Glycine Receptor.Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site.
P2860
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P2860
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
description
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2005
@ast
im November 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/11/11)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/11/11)
@nl
наукова стаття, опублікована в листопаді 2005
@uk
name
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
@ast
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
@en
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
@nl
type
label
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
@ast
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
@en
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
@nl
prefLabel
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
@ast
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
@en
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
@nl
P2860
P3181
P356
P1476
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
@en
P2093
Helena M A Da Silva
Trevor G Smart
P2860
P304
37877-37884
P3181
P356
10.1074/JBC.M508303200
P407
P577
2005-09-06T00:00:00Z