A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation
about
Community structure analysis of transcriptional networks reveals distinct molecular pathways for early- and late-onset temporal lobe epilepsy with childhood febrile seizuresLoss of synaptic Zn2+ transporter function increases risk of febrile seizuresMutations in SLC12A5 in epilepsy of infancy with migrating focal seizures.Cation-chloride cotransporters in neuronal development, plasticity and diseaseKCC2 activity is critical in limiting the onset and severity of status epilepticus.Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures.Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures.Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophreniaDetrimental effect of post Status Epilepticus treatment with ROCK inhibitor Y-27632 in a pilocarpine model of temporal lobe epilepsy.A noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells.The intolerance to functional genetic variation of protein domains predicts the localization of pathogenic mutations within genes.Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target.Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delayMethyl-CpG-Binding Protein MBD1 Regulates Neuronal Lineage Commitment through Maintaining Adult Neural Stem Cell IdentityCompromising KCC2 transporter activity enhances the development of continuous seizure activity.Locus Heterogeneity in Epilepsy of Infancy with Migrating Focal Seizures.The role of nicotinic acetylcholine receptors in autosomal dominant nocturnal frontal lobe epilepsy.Generation of Febrile Seizures and Subsequent Epileptogenesis.Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy.Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain.WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2The membrane trafficking and functionality of the K+-Cl- co-transporter KCC2 is regulated by TGF-β2.The KCl-cotransporter KCC2 linked to epilepsy.Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibitionA kainate receptor subunit promotes the recycling of the neuron-specific K+-Cl- co-transporter KCC2 in hippocampal neurons.Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome.Differential regulation of chloride homeostasis and GABAergic transmission in the thalamusThe Effects of Ginsenoside Compound K Against Epilepsy by Enhancing the γ-Aminobutyric Acid Signaling PathwayDose-dependent reversal of KCC2 hypofunction and phenobarbital-resistant neonatal seizures by ANA12
P2860
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P2860
A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation
description
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2014
@ast
im Juni 2014 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2014/06/01)
@sk
vědecký článek publikovaný v roce 2014
@cs
wetenschappelijk artikel (gepubliceerd op 2014/06/01)
@nl
наукова стаття, опублікована в червні 2014
@uk
مقالة علمية (نشرت في يونيو 2014)
@ar
name
A variant of KCC2 from patient ...... and dendritic spine formation
@ast
A variant of KCC2 from patient ...... and dendritic spine formation
@en
A variant of KCC2 from patient ...... and dendritic spine formation
@nl
type
label
A variant of KCC2 from patient ...... and dendritic spine formation
@ast
A variant of KCC2 from patient ...... and dendritic spine formation
@en
A variant of KCC2 from patient ...... and dendritic spine formation
@nl
prefLabel
A variant of KCC2 from patient ...... and dendritic spine formation
@ast
A variant of KCC2 from patient ...... and dendritic spine formation
@en
A variant of KCC2 from patient ...... and dendritic spine formation
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
A variant of KCC2 from patient ...... and dendritic spine formation
@en
P2093
Bronwyn E. Grinton
Faraz Ahmad
Ingrid E. Scheffer
Karen L. Oliver
Laszlo Vutskits
Leanne M. Dibbens
Patricia Seja
Peter Blaesse
Samuel F. Berkovic
Sarah E. Heron
P2860
P304
P3181
P356
10.1002/EMBR.201438749
P577
2014-06-01T00:00:00Z