An activated L-selectin mutant with conserved equilibrium binding properties but enhanced ligand recognition under shear flow
about
Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic forceA structure-based sliding-rebinding mechanism for catch bonds.Flow-enhanced adhesion regulated by a selectin interdomain hinge.Transmission of allostery through the lectin domain in selectin-mediated cell adhesion.Visualization of allostery in P-selectin lectin domain using MD simulations.Kinetics of GPIbalpha-vWF-A1 tether bond under flow: effect of GPIbalpha mutations on the association and dissociation rates.Prophylactic use of epidermal growth factor reduces ischemia/reperfusion intestinal damageCytoplasmic anchorage of L-selectin controls leukocyte capture and rolling by increasing the mechanical stability of the selectin tether.Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domainAvidity enhancement of L-selectin bonds by flow: shear-promoted rotation of leukocytes turn labile bonds into functional tethers.Distinct molecular and cellular contributions to stabilizing selectin-mediated rolling under flow.Structural basis for selectin mechanochemistryBiomolecule association rates do not provide a complete description of bond formation.Catch-bond mechanism of force-enhanced adhesion: counterintuitive, elusive, but ... widespread?Quantifying the effects of molecular orientation and length on two-dimensional receptor-ligand binding kinetics.The S128R polymorphism of E-selectin mediates neuraminidase-resistant tethering of myeloid cells under shear flow.L-selectin dimerization enhances tether formation to properly spaced ligand.Endothelial chemokines destabilize L-selectin-mediated lymphocyte rolling without inducing selectin shedding.The CD81 tetraspanin facilitates instantaneous leukocyte VLA-4 adhesion strengthening to vascular cell adhesion molecule 1 (VCAM-1) under shear flow.Reducing Macro- and Microheterogeneity of N-Glycans Enables the Crystal Structure of the Lectin and EGF-Like Domains of Human L-Selectin To Be Solved at 1.9 Å Resolution.
P2860
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P2860
An activated L-selectin mutant with conserved equilibrium binding properties but enhanced ligand recognition under shear flow
description
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2000
@ast
im Juni 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/06/23)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/06/23)
@nl
наукова стаття, опублікована в червні 2000
@uk
name
An activated L-selectin mutant ...... d recognition under shear flow
@ast
An activated L-selectin mutant ...... d recognition under shear flow
@en
An activated L-selectin mutant ...... d recognition under shear flow
@nl
type
label
An activated L-selectin mutant ...... d recognition under shear flow
@ast
An activated L-selectin mutant ...... d recognition under shear flow
@en
An activated L-selectin mutant ...... d recognition under shear flow
@nl
prefLabel
An activated L-selectin mutant ...... d recognition under shear flow
@ast
An activated L-selectin mutant ...... d recognition under shear flow
@en
An activated L-selectin mutant ...... d recognition under shear flow
@nl
P2860
P356
P1476
An activated L-selectin mutant ...... d recognition under shear flow
@en
P2093
P2860
P304
18682-18691
P356
10.1074/JBC.M001103200
P407
P50
P577
2000-06-01T00:00:00Z