Functional specialization in proline biosynthesis of melanoma
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Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and HypomyelinationMetabolic rewiring in melanomaCutis laxa: intersection of elastic fiber biogenesis, TGFβ signaling, the secretory pathway and metabolismMetabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway.Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides.PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress.Therapeutic interventions to disrupt the protein synthetic machinery in melanomaBridging epigenetics and metabolism: role of non-essential amino acidsPYCR2 Mutations cause a lethal syndrome of microcephaly and failure to thrive.Proline mechanisms of stress survival.Evolution of proline biosynthesis: enzymology, bioinformatics, genetics, and transcriptional regulation.Mitochondria as biosynthetic factories for cancer proliferation.Tumour-specific proline vulnerability uncovered by differential ribosome codon reading.Downregulation of pyrroline-5-carboxylate reductase-2 induces the autophagy of melanoma cells via AMPK/mTOR pathway.Hypomyelinating leukodystrophies - a molecular insight into the white matter pathology.Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers.Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1.Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis.Eutrophication and the dietary promotion of sea turtle tumors.Glutamate and asparagine cataplerosis underlie glutamine addiction in melanomaRight on TARGET: glutamine metabolism in cancer.L-Proline uptake in Saccharomyces cerevisiae mitochondria can contribute to bioenergetics during nutrient stress as alternative mitochondrial fuel.Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications.Pyrroline-5-carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non-small cell lung cancer.PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-ProPYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-ProPYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-ProEvidence for Pipecolate Oxidase in Mediating Protection Against Hydrogen Peroxide Stress.Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.Homozygous variants in pyrroline-5-carboxylate reductase 2 (PYCR2) in patients with progressive microcephaly and hypomyelinating leukodystrophy.The Proline Cycle As a Potential Cancer Therapy Target.Genome-wide association study reveals a QTL and strong candidate genes for umbilical hernia in pigs on SSC14.Amino Acid Signature in Human Melanoma Cell Lines from Different Disease Stages.
P2860
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P2860
Functional specialization in proline biosynthesis of melanoma
description
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique PLoS ONE
@fr
artikull shkencor
@sq
artículu científicu espublizáu en 2012
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im Januar 2012 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в січні 2012
@uk
مقالة علمية (نشرت عام 2012)
@ar
name
Functional specialization in proline biosynthesis of melanoma
@ast
Functional specialization in proline biosynthesis of melanoma
@en
Functional specialization in proline biosynthesis of melanoma
@nl
type
label
Functional specialization in proline biosynthesis of melanoma
@ast
Functional specialization in proline biosynthesis of melanoma
@en
Functional specialization in proline biosynthesis of melanoma
@nl
prefLabel
Functional specialization in proline biosynthesis of melanoma
@ast
Functional specialization in proline biosynthesis of melanoma
@en
Functional specialization in proline biosynthesis of melanoma
@nl
P2093
P2860
P921
P3181
P1433
P1476
Functional specialization in proline biosynthesis of melanoma
@en
P2093
Adam D. Richardson
Andrei L. Osterman
Boris Ratnikov
David A. Scott
Jeffrey W. Smith
Jessica De Ingeniis
Marat Kazanov
Pedro Aza-Blanc
Surya K. De
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0045190
P407
P577
2012-01-01T00:00:00Z