Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction
about
Dubowitz syndrome is a complex comprised of multiple, genetically distinct and phenotypically overlapping disordersDNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cellsCockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation.Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining.Analysis of the role of homology arms in gene-targeting vectors in human cells53BP1 mediates the fusion of mammalian telomeres rendered dysfunctional by DNA-PKcs loss or inhibition.Complex interactions between the DNA-damage response and mammalian telomeres.LIG4 mediates Wnt signalling-induced radioresistance.Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent CellsSister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4.Alternative end joining, clonal evolution, and escape from a telomere-driven crisis.Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells.Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity.A role for XLF in DNA repair and recombination in human somatic cells.The synthetic lethal killing of RAD54B-deficient colorectal cancer cells by PARP1 inhibition is enhanced with SOD1 inhibition.Mechanistic basis for increased human gene targeting by promoterless vectors-roles of homology arms and Rad54 paralogs.Human somatic cells deficient for RAD52 are impaired for viral integration and compromised for most aspects of homology-directed repair.The enigmatic oncogene and tumor suppressor-like properties of RAD54B: Insights into genome instability and cancer.DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining.The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining.FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.Predicting efficacies of anticancer drugs using single cell HaloChip assay.PARP1 is required for preserving telomeric integrity but is dispensable for A-NHEJ
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P2860
Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction
description
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2013
@ast
im Februar 2013 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
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vedecký článok (publikovaný 2013/02/01)
@sk
vědecký článek publikovaný v roce 2013
@cs
wetenschappelijk artikel (gepubliceerd op 2013/02/01)
@nl
наукова стаття, опублікована в лютому 2013
@uk
مقالة علمية (نشرت في فبراير 2013)
@ar
name
Human LIGIV is synthetically l ...... nduced by telomere dysfunction
@ast
Human LIGIV is synthetically l ...... nduced by telomere dysfunction
@en
Human LIGIV is synthetically l ...... nduced by telomere dysfunction
@nl
type
label
Human LIGIV is synthetically l ...... nduced by telomere dysfunction
@ast
Human LIGIV is synthetically l ...... nduced by telomere dysfunction
@en
Human LIGIV is synthetically l ...... nduced by telomere dysfunction
@nl
prefLabel
Human LIGIV is synthetically l ...... nduced by telomere dysfunction
@ast
Human LIGIV is synthetically l ...... nduced by telomere dysfunction
@en
Human LIGIV is synthetically l ...... nduced by telomere dysfunction
@nl
P2093
P2860
P3181
P356
P1476
Human LIGIV is synthetically l ...... nduced by telomere dysfunction
@en
P2093
Eric A. Hendrickson
Jacob Zimbric
Yongbao Wang
P2860
P304
P3181
P356
10.1093/NAR/GKS1326
P407
P577
2013-02-01T00:00:00Z