Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells
about
DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formationDNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cellsTargeting abnormal DNA repair in therapy-resistant breast cancersDNA damage and repair in plants - from models to cropsCross talk of tyrosine kinases with the DNA damage signaling pathwaysHomologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian CancerPhysiology of the read-write genomeThe role of RecQ helicases in non-homologous end-joiningDifferential requirement for SUB1 in chromosomal and plasmid double-strand DNA break repairTRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeresHuman LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunctionATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaksDefective nonhomologous end joining blocks B-cell development in FLT3/ITD miceThe HSV-1 exonuclease, UL12, stimulates recombination by a single strand annealing mechanismThe intersection between DNA damage response and cell death pathwaysAnd-1 coordinates with CtIP for efficient homologous recombination and DNA damage checkpoint maintenanceCancer risk at low doses of ionizing radiation: artificial neural networks inference from atomic bomb survivors.Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining.Breaking news: plants mutate right on targetSingle molecule PCR reveals similar patterns of non-homologous DSB repair in tobacco and Arabidopsis.Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias.DNA ligases as therapeutic targetsSimple monitoring of gene targeting efficiency in human somatic cell lines using the PIGA gene.Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation.Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts.Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans.Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells.The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair.Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaksSubtelomeric regions in mammalian cells are deficient in DNA double-strand break repair.Choosing the right path: does DNA-PK help make the decision?On the sequence-directed nature of human gene mutation: the role of genomic architecture and the local DNA sequence environment in mediating gene mutations underlying human inherited disease.A comparative analysis of constitutive promoters located in adeno-associated viral vectors.Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining.Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathwayIdentification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors.KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining RepairThe Catalytic Subunit of DNA-Dependent Protein Kinase Coordinates with Polo-Like Kinase 1 to Facilitate Mitotic Entry.Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context.5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair.
P2860
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P2860
Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Ku regulates the non-homologou ...... repair in human somatic cells
@ast
Ku regulates the non-homologou ...... repair in human somatic cells
@en
Ku regulates the non-homologou ...... repair in human somatic cells
@en-gb
Ku regulates the non-homologou ...... repair in human somatic cells
@nl
type
label
Ku regulates the non-homologou ...... repair in human somatic cells
@ast
Ku regulates the non-homologou ...... repair in human somatic cells
@en
Ku regulates the non-homologou ...... repair in human somatic cells
@en-gb
Ku regulates the non-homologou ...... repair in human somatic cells
@nl
altLabel
Ku Regulates the Non-Homologou ...... Repair in Human Somatic Cells
@en
prefLabel
Ku regulates the non-homologou ...... repair in human somatic cells
@ast
Ku regulates the non-homologou ...... repair in human somatic cells
@en
Ku regulates the non-homologou ...... repair in human somatic cells
@en-gb
Ku regulates the non-homologou ...... repair in human somatic cells
@nl
P2093
P2860
P4510
P3181
P1433
P1476
Ku regulates the non-homologou ...... repair in human somatic cells
@en
P2093
Eric A Hendrickson
Eu Han Lee
Farjana Fattah
Natalie Lichter
Natalie Weisensel
Yongbao Wang
P2860
P304
P3181
P356
10.1371/JOURNAL.PGEN.1000855
P407
P577
2010-02-01T00:00:00Z