Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation
about
Protein kinase cascades in the regulation of cardiac hypertrophyProtein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5PKC translocation and ERK1/2 activation in compensated right ventricular hypertrophy secondary to chronic emphysemaMechanisms of altered Ca²⁺ handling in heart failureCyclic mechanical strain of myocytes modifies CapZβ1 post translationally via PKCεThe alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mousePKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2)Crosstalk between adenosine A1 and β1-adrenergic receptors regulates translocation of PKCε in isolated rat cardiomyocytesMammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats.Protein Kinases as Drug Development Targets for Heart Disease TherapyOpposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC.Modulation of the protein kinase Cdelta interaction with the "d" subunit of F1F0-ATP synthase in neonatal cardiac myocytes: development of cell-permeable, mitochondrially targeted inhibitor and facilitator peptides.Mineralocorticoid accelerates transition to heart failure with preserved ejection fraction via "nongenomic effects".Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart FailureProtein kinase Cθ is required for cardiomyocyte survival and cardiac remodeling.Plasma membrane mechanisms in a preclinical rat model of chronic painβIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failureReceptor-independent protein kinase C alpha (PKCalpha) signaling by calpain-generated free catalytic domains induces HDAC5 nuclear export and regulates cardiac transcription.Distinctive activation mechanisms and functions for protein kinase Cdelta.Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptideMuscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophyPhosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy.Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growthProtein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase AGenetic approaches for changing the heart and dissecting complex syndromes.Protein kinase C, an elusive therapeutic target?Protein kinase C in heart failure: a therapeutic target?Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart.Inhibition of DNA methylation reverses norepinephrine-induced cardiac hypertrophy in rats.Mitochondrial protein phosphorylation as a regulatory modality: implications for mitochondrial dysfunction in heart failure.PRKCE gene encoding protein kinase C-epsilon-Dual roles at sarcomeres and mitochondria in cardiomyocytes.Protein kinase C and cardiac dysfunction: a review.Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy.In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate.Docosahexaenoic acid inhibits protein kinase C translocation/activation and cardiac hypertrophy in rat cardiomyocytes.Protein phosphatase 1 and an opposing protein kinase regulate steady-state L-type Ca2+ current in mouse cardiac myocytes.Research advances in kinase enzymes and inhibitors for cardiovascular disease treatment.
P2860
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P2860
Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation
description
2000 nî lūn-bûn
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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Cardiotrophic effects of prote ...... on of PKCepsilon translocation
@ast
Cardiotrophic effects of prote ...... on of PKCepsilon translocation
@en
Cardiotrophic effects of prote ...... on of PKCepsilon translocation
@nl
type
label
Cardiotrophic effects of prote ...... on of PKCepsilon translocation
@ast
Cardiotrophic effects of prote ...... on of PKCepsilon translocation
@en
Cardiotrophic effects of prote ...... on of PKCepsilon translocation
@nl
prefLabel
Cardiotrophic effects of prote ...... on of PKCepsilon translocation
@ast
Cardiotrophic effects of prote ...... on of PKCepsilon translocation
@en
Cardiotrophic effects of prote ...... on of PKCepsilon translocation
@nl
P2093
P1433
P1476
Cardiotrophic effects of prote ...... on of PKCepsilon translocation
@en
P2093
D Mochly-Rosen
J N Lorenz
P304
P407
P577
2000-06-09T00:00:00Z