A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression
about
Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signalingProtein phosphatase 1 regulates assembly and function of the beta-catenin degradation complexDirect inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signalingMethylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signalingWnt/beta-catenin signaling and small molecule inhibitorsGSK-3: tricks of the trade for a multi-tasking kinaseSUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stabilityThe links between axin and carcinogenesisToggling a conformational switch in Wnt/β-catenin signaling: regulation of Axin phosphorylation. The phosphorylation state of Axin controls its scaffold function in two Wnt pathway protein complexesGSK-3 as potential target for therapeutic intervention in cancerBoth the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesisInhibition of Wnt signaling pathway by a novel axin-binding proteinWnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway.Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes.GSK-3: Functional Insights from Cell Biology and Animal Models.Expression and characterization of GSK-3 mutants and their effect on beta-catenin phosphorylation in intact cells.GSK3 takes centre stage more than 20 years after its discovery.Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes.Regulation of Wnt/beta-catenin signaling by protein kinasesCadherin sequences that inhibit beta-catenin signaling: a study in yeast and mammalian cells.Physiological roles of glycogen synthase kinase-3: potential as a therapeutic target for diabetes and other disorders.A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?Expression Pattern of Axin2 During Chicken DevelopmentFrizzled and LRP5/6 receptors for Wnt/β-catenin signalingBeyond cell adhesion: the role of armadillo proteins in the heartRole of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions.Phospho-regulation of Beta-catenin adhesion and signaling functions.The terminal region of beta-catenin promotes stability by shielding the Armadillo repeats from the axin-scaffold destruction complex.New insights into the regulation of Axin function in canonical Wnt signaling pathway.Regulation of Wnt/β-catenin signaling by posttranslational modificationsPP2A as a master regulator of the cell cycle.Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancerWnt Signaling Polarizes C. elegans Asymmetric Cell Divisions During Development.The amyloid-beta peptide suppresses transforming growth factor-beta1-induced matrix metalloproteinase-2 production via Smad7 expression in human monocytic THP-1 cells.Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin.Mouse axin and axin2/conductin proteins are functionally equivalent in vivoWnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies.Ectopic expression of Axin blocks neuronal differentiation of embryonic carcinoma P19 cells.Disassembly of the destruction complex and recruitment of AXIN to the membrane
P2860
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P2860
A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
A GSK3beta phosphorylation sit ...... d Tcf-mediated gene expression
@ast
A GSK3beta phosphorylation sit ...... d Tcf-mediated gene expression
@en
A GSK3beta phosphorylation sit ...... d Tcf-mediated gene expression
@nl
type
label
A GSK3beta phosphorylation sit ...... d Tcf-mediated gene expression
@ast
A GSK3beta phosphorylation sit ...... d Tcf-mediated gene expression
@en
A GSK3beta phosphorylation sit ...... d Tcf-mediated gene expression
@nl
prefLabel
A GSK3beta phosphorylation sit ...... d Tcf-mediated gene expression
@ast
A GSK3beta phosphorylation sit ...... d Tcf-mediated gene expression
@en
A GSK3beta phosphorylation sit ...... d Tcf-mediated gene expression
@nl
P2093
P3181
P356
P1476
A GSK3beta phosphorylation sit ...... d Tcf-mediated gene expression
@en
P2093
F Costantini
S Lomvardas
P3181
P356
10.1006/BBRC.1999.1760
P407
P577
1999-12-09T00:00:00Z