RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1
about
Muscleblind proteins regulate alternative splicingInteraction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicingCELF6, a member of the CELF family of RNA-binding proteins, regulates muscle-specific splicing enhancer-dependent alternative splicingCalreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteinsMBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1Epidermal growth factor receptor stimulation activates the RNA binding protein CUG-BP1 and increases expression of C/EBPbeta-LIP in mammary epithelial cellsFailure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophyMyotonic dystrophy protein kinase is critical for nuclear envelope integrityMolecular basis for impaired muscle differentiation in myotonic dystrophyElevation of RNA-binding protein CUGBP1 is an early event in an inducible heart-specific mouse model of myotonic dystrophyCUG-BP1/CELF1 requires UGU-rich sequences for high-affinity bindingDefining early steps in mRNA transport: mutant mRNA in myotonic dystrophy type I is blocked at entry into SC-35 domains.HnRNP H inhibits nuclear export of mRNA containing expanded CUG repeats and a distal branch point sequence.Feedback Regulation of Kinase Signaling Pathways by AREs and GREsThe importance of CELF control: molecular and biological roles of the CUG-BP, Elav-like family of RNA-binding proteinsMyotonic dystrophy: is a narrow focus obscuring the rest of the field?The unstable repeats--three evolving faces of neurological diseaseModeling diseases of noncoding unstable repeat expansions using mutant pluripotent stem cells.The regulatory element in the 3'-untranslated region of human papillomavirus 16 inhibits expression by binding CUG-binding protein 1MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1RNA phase transitions in repeat expansion disorders.Disease Phenotypes in a Mouse Model of RNA Toxicity Are Independent of Protein Kinase Cα and Protein Kinase CβEvaluating the effects of CELF1 deficiency in a mouse model of RNA toxicityExpanded CTG repeats within the DMPK 3' UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophyWoodchuck post-transcriptional element induces nuclear export of myotonic dystrophy 3' untranslated region transcripts.PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1.CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1.Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.Expanded CCUG repeat RNA expression in Drosophila heart and muscle trigger Myotonic Dystrophy type 1-like phenotypes and activate autophagocytosis genes.Repression of nuclear CELF activity can rescue CELF-regulated alternative splicing defects in skeletal muscle models of myotonic dystrophyThe neurofibromatosis type I pre-mRNA is a novel target of CELF protein-mediated splicing regulation.Fragile X-Associated Tremor/Ataxia Syndrome: From Molecular Pathogenesis to Development of Therapeutics.Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1.Targeting DMPK with Antisense Oligonucleotide Improves Muscle Strength in Myotonic Dystrophy Type 1 MiceAberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy.Long tract of untranslated CAG repeats is deleterious in transgenic miceMyotonic dystrophies 1 and 2: complex diseases with complex mechanisms.Expression of a dominant negative CELF protein in vivo leads to altered muscle organization, fiber size, and subtype.p21(WAF1/CIP1) upregulation through the stress granule-associated protein CUGBP1 confers resistance to bortezomib-mediated apoptosis.The RNA-binding protein CUG-BP1 increases survivin expression in oesophageal cancer cells through enhanced mRNA stability.
P2860
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P2860
RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1
@ast
RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1
@en
RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1
@nl
type
label
RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1
@ast
RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1
@en
RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1
@nl
prefLabel
RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1
@ast
RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1
@en
RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1
@nl
P2093
P2860
P3181
P356
P1476
RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.M005960200
P407
P577
2001-03-16T00:00:00Z