Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach
about
Clobazam and its active metabolite N-desmethylclobazam display significantly greater affinities for α₂- versus α₁-GABA(A)-receptor complexesA Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor ModelGABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism.The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala.Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups.Selective targeting of the α5-subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handlingDigital Image Analysis for DETCHIP(®) Code Determination.Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse.Classics in chemical neuroscience: diazepam (valium).The GABA(A) receptor as a target for photochromic molecules.Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma.Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations.Flunitrazepam in combination with alcohol engenders high levels of aggression in mice and rats.First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development.Antagonism of triazolam self-administration in rhesus monkeys responding under a progressive-ratio schedule: In vivo apparent pA2 analysis.Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding siteA study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysisDesign, Synthesis and Anticonvulsant Activity of 2-(2-Phenoxy) phenyl- 1,3,4-oxadiazole DerivativesDesign, Synthesis and Pharmacological Evaluation of Novel 2-[2-(2-Chlorophenoxy) phenyl]-1,3,4-oxadiazole Derivatives as Benzodiazepine Receptor Agonists.Modulation of α5 subunit-containing GABAA receptors alters alcohol drinking by rhesus monkeys.Little evidence of a role for the α1GABAA subunit-containing receptor in a rhesus monkey model of alcohol drinking.Effects of the benzodiazepine GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on alcohol seeking and self-administration in baboons.The differential role of alpha1- and alpha5-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats.Dissociating anxiolytic and sedative effects of GABAAergic drugs using temperature and locomotor responses to acute stress.The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in ratsEffects of the benzodiazepine GABAA α1-preferring antagonist 3-isopropoxy-β-carboline hydrochloride (3-ISOPBC) on alcohol seeking and self-administration in baboons.
P2860
Q21090654-58C78B65-1E01-46C0-BFEE-F5C787FEC09EQ26774869-6B8A8990-E571-444E-A5F2-995FE29755ECQ30421260-F61C8F3A-0D10-46E1-AA1C-89A23F8F8737Q30438111-E0D34F33-1E95-4E90-8053-09B8039973BDQ30486159-AC4C1161-1066-42BC-ADC2-FAE18EFA7FADQ30647960-C9C31EE1-8F4E-4A98-81D8-1FCBB8F57FDBQ34251257-E50F069F-E438-4BCD-B913-573144FF5A01Q34275459-936A51B5-B3A9-4CD8-9C55-711900625F57Q34405394-C8B90A3A-C02A-48D9-AF43-D746EEE416FDQ34520855-17362B0C-8C7D-4F73-AD9F-84553EE1D9C0Q34609220-E302C823-A500-4EF8-B3B7-0D8950AC3F80Q35061649-EF8C6773-D5DB-44DA-9C5F-E40325DAF366Q35588239-1C218ACD-AC30-4DD4-A47B-A1274A7C483EQ36056262-B6D4210C-F487-49FA-8983-293225108968Q36421449-30399F62-4F8B-45A7-86D3-2DFC076DC402Q36935606-D30CBC02-5676-4BB4-B8F9-DFEA423C179FQ36990611-FCC7C4CD-48DE-48DE-9217-3F4617A986A7Q37268757-EF93BBFD-2F33-4222-8618-1C8AF7DFBE35Q37422129-9202A6A8-74F0-46F9-BC6A-C7D83A5CD201Q37633927-6251CF43-C4AC-4A43-A8BB-710167B7B2E1Q37698992-A0C978B6-AA11-4FD5-88F5-7AF2492E6796Q39784438-2C458D82-A65A-49AB-A489-A1EA573C602FQ41812558-8EC24D3A-9C80-46C8-B835-79AE39AA3085Q42567743-69D5BCFD-F98B-4E54-904D-A7AAECD6A9F2Q42592909-9984CD47-4F6C-4A0B-90EE-612ADCDAD2BAQ47383106-CAC0F640-988B-4F15-9809-82710F2DB26E
P2860
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Pharmacophore/receptor models ...... ensive ligand-mapping approach
@ast
Pharmacophore/receptor models ...... ensive ligand-mapping approach
@en
Pharmacophore/receptor models ...... ensive ligand-mapping approach
@nl
type
label
Pharmacophore/receptor models ...... ensive ligand-mapping approach
@ast
Pharmacophore/receptor models ...... ensive ligand-mapping approach
@en
Pharmacophore/receptor models ...... ensive ligand-mapping approach
@nl
prefLabel
Pharmacophore/receptor models ...... ensive ligand-mapping approach
@ast
Pharmacophore/receptor models ...... ensive ligand-mapping approach
@en
Pharmacophore/receptor models ...... ensive ligand-mapping approach
@nl
P2093
P1476
Pharmacophore/receptor models ...... ensive ligand-mapping approach
@en
P2093
G R Wenger
R McKernan
P407
P577
2000-01-13T00:00:00Z