GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex
about
Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffoldMIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase deltaErk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASPProtein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASPMagicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2Dynamin at actin tails.Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagementA WASp-VASP complex regulates actin polymerization at the plasma membrane.Motility determinants in WASP family proteins.Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's diseaseA novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42Molecular mechanism of protrusion formation during cell-to-cell spread of ListeriaUnder lock and key: spatiotemporal regulation of WASP family proteins coordinates separate dynamic cellular processesSaccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitromDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber formationThe C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motifPhosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cellsActin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells.Neph1 cooperates with nephrin to transduce a signal that induces actin polymerizationActivation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complexMechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphateGrb2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner.Allosteric N-WASP activation by an inter-SH3 domain linker in NckStoichiometry of Nck-dependent actin polymerization in living cellsMembrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli.Physical mechanisms of signal integration by WASP family proteins.Gas7 functions with N-WASP to regulate the neurite outgrowth of hippocampal neurons.Regulation of actin polymerization and adhesion-dependent cell edge protrusion by the Abl-related gene (Arg) tyrosine kinase and N-WASp.Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation.The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle.Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signalingCR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein familyRegulation of N-WASP and the Arp2/3 complex by Abp1 controls neuronal morphologyWiskott-Aldrich syndrome: a comprehensive review.Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity.A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions.The Ras/Rac guanine nucleotide exchange factor mammalian Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton.How WASP regulates actin polymerization.Role of the WASP family proteins for Mycobacterium marinum actin tail formation.
P2860
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P2860
GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex
description
2000 nî lūn-bûn
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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
GRB2 links signaling to actin ...... lated protein (ARP2/3) complex
@ast
GRB2 links signaling to actin ...... lated protein (ARP2/3) complex
@en
GRB2 links signaling to actin ...... lated protein (ARP2/3) complex
@nl
type
label
GRB2 links signaling to actin ...... lated protein (ARP2/3) complex
@ast
GRB2 links signaling to actin ...... lated protein (ARP2/3) complex
@en
GRB2 links signaling to actin ...... lated protein (ARP2/3) complex
@nl
prefLabel
GRB2 links signaling to actin ...... lated protein (ARP2/3) complex
@ast
GRB2 links signaling to actin ...... lated protein (ARP2/3) complex
@en
GRB2 links signaling to actin ...... lated protein (ARP2/3) complex
@nl
P2093
P2860
P356
P1476
GRB2 links signaling to actin ...... lated protein (ARP2/3) complex
@en
P2093
D Pantaloni
I Broutin-L'Hermite
M F Carlier
R Boujemaa
P2860
P304
P356
10.1074/JBC.M000687200
P407
P577
2000-07-21T00:00:00Z