The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling
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SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreadingThe Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cellsSHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKLG6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2SHIP2 multiple functions: a balance between a negative control of PtdIns(3,4,5)P₃ level, a positive control of PtdIns(3,4)P₂ production, and intrinsic docking properties.Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.Insufficient phosphorylation prevents fc gamma RIIB from recruiting the SH2 domain-containing protein-tyrosine phosphatase SHP-1.Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position.Involvement of Fc receptors in disorders of the central nervous system.LyGDI, a novel SHIP-interacting protein, is a negative regulator of FcγR-mediated phagocytosis.Regulation of the mast cell response to the type 1 Fc epsilon receptor.Survival of monocytes and macrophages and their role in health and disease.FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model.SHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor.Biochemistry and structure of phosphoinositide phosphatases.Molecular basis of the recruitment of the SH2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 by fcgamma RIIB.SHIP2: Structure, Function and Inhibition.How does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity?Motif decomposition of the phosphotyrosine proteome reveals a new N-terminal binding motif for SHIP2.SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels.EMBO WORKSHOP REPORT: lymphocyte antigen receptor and coreceptor signaling Siena, Italy, November 6-10, 1999.Src homology 2 domain-containing inositol 5-phosphatase 1 mediates cell cycle arrest by FcgammaRIIB.Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides.
P2860
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P2860
The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling
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2000年の論文
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The SH2 domain containing inos ...... cells under negative signaling
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The SH2 domain containing inos ...... cells under negative signaling
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The SH2 domain containing inos ...... cells under negative signaling
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The SH2 domain containing inos ...... cells under negative signaling
@ast
The SH2 domain containing inos ...... cells under negative signaling
@en
The SH2 domain containing inos ...... cells under negative signaling
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The SH2 domain containing inos ...... cells under negative signaling
@ast
The SH2 domain containing inos ...... cells under negative signaling
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The SH2 domain containing inos ...... cells under negative signaling
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The SH2 domain containing inos ...... cells under negative signaling
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10.1016/S0165-2478(00)00162-0
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2000-04-03T00:00:00Z