G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2
about
Platelet signaling: a complex interplay between inhibitory and activatory networksAn investigation of hierachical protein recruitment to the inhibitory platelet receptor, G6B-bMice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet functionMolecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).Endothelial cell specific adhesion molecule (ESAM) localizes to platelet-platelet contacts and regulates thrombus formation in vivoPhospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation.Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex.CLEC-2 expression is maintained on activated platelets and on platelet microparticles.Phosphoproteomic analysis of platelets activated by pro-thrombotic oxidized phospholipids and thrombin.G6f-like is an ITAM-containing collagen receptor in thrombocytes.Historical perspective and future directions in platelet research.The Y's that bind: negative regulators of Src family kinase activity in platelets.Junctional adhesion molecule-A suppresses platelet integrin αIIbβ3 signaling by recruiting Csk to the integrin-c-Src complex.Novel platelet activation receptor CLEC-2: from discovery to prospects.The C-type lectin-like receptors of Dectin-1 cluster in natural killer gene complex.Platelet receptors activated via mulitmerization: glycoprotein VI, GPIb-IX-V, and CLEC-2.Src family kinases: at the forefront of platelet activationITIM receptors: more than just inhibitors of platelet activation.Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides.CLEC-2 activates Syk through dimerization.Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signalingNegative regulators of platelet activation and adhesion.G6B binds PTPN6;PTPN11
P2860
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P2860
G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2
@ast
G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2
@en
type
label
G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2
@ast
G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2
@en
prefLabel
G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2
@ast
G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2
@en
P2093
P2860
P50
P921
P356
P1476
G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2
@en
P2093
Andrew C Pearce
Beata Grygielska
Jennifer C Spalton
Johannes A Eble
P2860
P304
35419-35427
P356
10.1074/JBC.M806895200
P407
P577
2008-10-27T00:00:00Z