Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA
about
A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization.Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responsesA mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinasesThe NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formationNek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylationMitotic regulation by NIMA-related kinasesNercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progressionAn Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation.Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivoTINA interacts with the NIMA kinase in Aspergillus nidulans and negatively regulates astral microtubules during metaphase arrestPurification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2.Characterization of the human NEK7 interactome suggests catalytic and regulatory properties distinct from those of NEK6The Nek2 protein kinase: a novel regulator of centrosome structure.C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting.NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome componentThe cell adhesion gene PVRL3 is associated with congenital ocular defects.Mitotic Regulation by NEK Kinase Networks.Downregulation of NIMA-related kinase-7 inhibits cell proliferation by inducing cell cycle arrest in human retinoblastoma cells.Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression.Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6Regulation of Nek6 functions by its SUMOylation on the K252residueInvolvement of Nek2 in mammalian development as a cell cycle regulator
P2860
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P2860
Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA
description
2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Isolation and characterization ...... fungal mitotic regulator, NIMA
@ast
Isolation and characterization ...... fungal mitotic regulator, NIMA
@en
Isolation and characterization ...... fungal mitotic regulator, NIMA
@nl
type
label
Isolation and characterization ...... fungal mitotic regulator, NIMA
@ast
Isolation and characterization ...... fungal mitotic regulator, NIMA
@en
Isolation and characterization ...... fungal mitotic regulator, NIMA
@nl
prefLabel
Isolation and characterization ...... fungal mitotic regulator, NIMA
@ast
Isolation and characterization ...... fungal mitotic regulator, NIMA
@en
Isolation and characterization ...... fungal mitotic regulator, NIMA
@nl
P2093
P356
P1433
P1476
Isolation and characterization ...... fungal mitotic regulator, NIMA
@en
P2093
P304
P356
10.1006/GENO.2000.6293
P407
P577
2000-09-01T00:00:00Z