The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation
about
No evidence of locus heterogeneity in familial microcephaly with or without chorioretinopathy, lymphedema, or mental retardation syndromeKinesin-5: cross-bridging mechanism to targeted clinical therapyNek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5Tyrosines in the kinesin-5 head domain are necessary for phosphorylation by Wee1 and for mitotic spindle integrityAn Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9Structural Analysis of the Regulation of the DYNLL/LC8 Binding to Nek9 by PhosphorylationThe NIMA-family kinase Nek3 regulates microtubule acetylation in neuronsCancer biomarker discovery: the entropic hallmark.Mechanism and regulation of kinesin-5, an essential motor for the mitotic spindle.Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression"Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinasesA high-throughput platform for lentiviral overexpression screening of the human ORFeome.NEK9-dependent proliferation of cancer cells lacking functional p53Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells.Characterization of the human NEK7 interactome suggests catalytic and regulatory properties distinct from those of NEK6C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting.Kinesin molecular motor Eg5 functions during polypeptide synthesis.Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy.Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer.Nek9 regulates spindle organization and cell cycle progression during mouse oocyte meiosis and its location in early embryo mitosisFbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic Kinesin Eg5.PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis.Regulation of mitosis by the NIMA kinase involves TINA and its newly discovered partner, An-WDR8, at spindle pole bodies.Breaking the ties that bind: new advances in centrosome biology.Cell cycle regulation by the NEK family of protein kinases.On the molecular mechanisms of mitotic kinase activation.The ciliary cytoskeleton.Intrinsic Disorder in the Kinesin Superfamily.Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer.The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistanceApoptosis signal-regulating kinase 1 promotes Ochratoxin A-induced renal cytotoxicity.Novel insights into the mechanisms of mitotic spindle assembly by NEK kinasesDYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9.Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.Mitotic Regulation by NEK Kinase Networks.Origin and evolution of B chromosomes in the cichlid fish Astatotilapia latifasciata based on integrated genomic analyses.Src family kinase phosphorylation of the motor domain of the human kinesin-5, Eg5.Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.
P2860
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P2860
The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The NIMA-family kinase Nek6 ph ...... for mitotic spindle formation
@ast
The NIMA-family kinase Nek6 ph ...... for mitotic spindle formation
@en
The NIMA-family kinase Nek6 ph ...... for mitotic spindle formation
@en-gb
The NIMA-family kinase Nek6 ph ...... for mitotic spindle formation
@nl
type
label
The NIMA-family kinase Nek6 ph ...... for mitotic spindle formation
@ast
The NIMA-family kinase Nek6 ph ...... for mitotic spindle formation
@en
The NIMA-family kinase Nek6 ph ...... for mitotic spindle formation
@en-gb
The NIMA-family kinase Nek6 ph ...... for mitotic spindle formation
@nl
prefLabel
The NIMA-family kinase Nek6 ph ...... for mitotic spindle formation
@ast
The NIMA-family kinase Nek6 ph ...... for mitotic spindle formation
@en
The NIMA-family kinase Nek6 ph ...... for mitotic spindle formation
@en-gb
The NIMA-family kinase Nek6 ph ...... for mitotic spindle formation
@nl
P2093
P2860
P921
P3181
P356
P1476
The NIMA-family kinase Nek6 ph ...... for mitotic spindle formation
@en
P2093
Aaron Groen
Carme Caelles
Joseph Avruch
Joseph Rapley
Laura Regué
Marta Nicolàs
P2860
P304
P3181
P356
10.1242/JCS.035360
P407
P577
2008-12-01T00:00:00Z