Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation - Wikidata - awgldk - TriplyDB

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

http://www.wikidata.org/entity/Q28145356

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Telomerase modulates Wnt signalling by association with target gene chromatin The telomere syndromes Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2 Repair of cyclobutane pyrimidine dimers or dimethylsulfate damage in DNA is identical in normal or telomerase-immortalized human skin fibroblasts.Aging and radiation: bad companions Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse Essential role of limiting telomeres in the pathogenesis of Werner syndrome A highly selective telomerase inhibitor limiting human cancer cell proliferation Natural and pharmacological regulation of telomerase Telomerase deficiency affects the formation of chromosomal translocations by homologous recombination in Saccharomyces cerevisiae.A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis.Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast.Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase Syndromes of telomere shortening On the capturing of low-energy electrons by DNA.The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging.Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors.The luminal progenitor compartment of the normal human mammary gland constitutes a unique site of telomere dysfunction.Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.The telomere/telomerase binding factor PinX1 is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomas.Telomere profiling: toward glioblastoma personalized medicine.Many ways to telomere dysfunction: in vivo studies using mouse models.Phosphorylation of H2AX at short telomeres in T cells and fibroblasts.Short telomeres induce a DNA damage response in Saccharomyces cerevisiae.Replication proteins influence the maintenance of telomere length and telomerase protein stability Telomere attrition and Chk2 activation in human heart failure Molecular parameters of hyperthermia for radiosensitization.Trastuzumab increases the sensitivity of HER2-amplified human gastric cancer cells to oxaliplatin and cisplatin by affecting the expression of telomere-associated proteins Molecular adaptation of telomere associated genes in mammals.Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells.Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells.Telomerase as a novel and potentially selective target for cancer chemotherapy.Reversibility of replicative senescence in Saccharomyces cerevisiae: effect of homologous recombination and cell cycle checkpoints.Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy

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P2860

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

http://www.wikidata.org/entity/Q28145356

description

2000 nî lūn-bûn

@nan

2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

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C Zhu

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10.1038/79232

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