A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates
about
A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimerInteracting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinasesA scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complexMetalloproteinase inhibitors, nonantimicrobial chemically modified tetracyclines, and ilomastat block Bacillus anthracis lethal factor activity in viable cellsA walk-through of the yeast mating pheromone response pathwaySpecificity of linear motifs that bind to a common mitogen-activated protein kinase docking grooveSelectivity of docking sites in MAPK kinasesIdentification of mitogen-activated protein kinase docking sites in enzymes that metabolize phosphatidylinositols and inositol phosphates.JNK signalling in cancer: in need of new, smarter therapeutic targetsCross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediatorsRole of mitogen-activated protein kinase kinase 4 in cancerComputational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factorsThe structural pathway of interleukin 1 (IL-1) initiated signaling reveals mechanisms of oncogenic mutations and SNPs in inflammation and cancerCombining docking site and phosphosite predictions to find new substrates: identification of smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrateStructural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.Characterization of an ERK-binding domain in microphthalmia-associated transcription factor and differential inhibition of ERK2-mediated substrate phosphorylation.Analysis of mitogen-activated protein kinase activation and interactions with regulators and substratesMechanisms of MAPK signalling specificity.Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo.Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitorThe BASL polarity protein controls a MAPK signaling feedback loop in asymmetric cell division.Norepinephrine increases blood pressure but not survival with anthrax lethal toxin in rats.Two hydrophobic residues can determine the specificity of mitogen-activated protein kinase docking interactions.A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1.Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice.Peptides targeting protein kinases: strategies and implications.Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids.Active stress kinases in proliferating endothelial cells associated with cytoskeletal structures.The beta-arrestin-2 scaffold protein promotes c-Jun N-terminal kinase-3 activation by binding to its nonconserved N terminus.Pathological axonal death through a MAPK cascade that triggers a local energy deficit.Insights into the anthrax lethal factor-substrate interaction and selectivity using docking and molecular dynamics simulations.Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs.Cloning and characterization of microbial activated Aedes aegypti MEK4 (AaMEK4): influences of noncatalytic domains on enzymatic activity.The Arabidopsis mitogen-activated protein kinase phosphatase PP2C5 affects seed germination, stomatal aperture, and abscisic acid-inducible gene expression.Atlantic salmon possess three mitogen activated protein kinase kinase 6 paralogs responding differently to stress.Non-ATP-competitive kinase inhibitors - enhancing selectivity through new inhibition strategies.Docking interactions in the c-Jun N-terminal kinase pathway.The critical features and the mechanism of inhibition of a kinase interaction motif-based peptide inhibitor of JNK.
P2860
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P2860
A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
A docking site in MKK4 mediate ...... ocking sites in JNK substrates
@ast
A docking site in MKK4 mediate ...... ocking sites in JNK substrates
@en
A docking site in MKK4 mediate ...... ocking sites in JNK substrates
@nl
type
label
A docking site in MKK4 mediate ...... ocking sites in JNK substrates
@ast
A docking site in MKK4 mediate ...... ocking sites in JNK substrates
@en
A docking site in MKK4 mediate ...... ocking sites in JNK substrates
@nl
prefLabel
A docking site in MKK4 mediate ...... ocking sites in JNK substrates
@ast
A docking site in MKK4 mediate ...... ocking sites in JNK substrates
@en
A docking site in MKK4 mediate ...... ocking sites in JNK substrates
@nl
P2093
P2860
P356
P1476
A docking site in MKK4 mediate ...... ocking sites in JNK substrates
@en
P2093
A Jane Bardwell
David T Ho
Mahsa Abdollahi
P2860
P304
P356
10.1074/JBC.M304229200
P407
P50
P577
2003-08-29T00:00:00Z