Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs.
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Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinasesSelectivity of docking sites in MAPK kinasesEpigenetics and bacterial infectionsLRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxinLung epithelial injury by B. anthracis lethal toxin is caused by MKK-dependent loss of cytoskeletal integritySuppressive effects of anthrax lethal toxin on megakaryopoiesisIdentification of novel non-hydroxamate anthrax toxin lethal factor inhibitors by topomeric searching, docking and scoring, and in vitro screening.Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent.Perturbation of mouse retinal vascular morphogenesis by anthrax lethal toxin.Bacillus anthracis lethal toxin disrupts TCR signaling in CD1d-restricted NKT cells leading to functional anergyMEK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 melanoma cells.Serum response factor regulates immediate early host gene expression in Toxoplasma gondii-infected host cells.Anthrax lethal toxin induces acute diastolic dysfunction in rats through disruption of the phospholamban signaling networkDevelopment of a comprehensive, validated pharmacophore hypothesis for anthrax toxin lethal factor (LF) inhibitors using genetic algorithms, Pareto scoring, and structural biology.Analysis of mitogen-activated protein kinase activation and interactions with regulators and substratesMechanisms of MAPK signalling specificity.Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo.Erythrocytic mobilization enhanced by the granulocyte colony-stimulating factor is associated with reduced anthrax-lethal-toxin-induced mortality in mice.Direct proteolytic cleavage of NLRP1B is necessary and sufficient for inflammasome activation by anthrax lethal factor.Erythropoiesis suppression is associated with anthrax lethal toxin-mediated pathogenic progressionAnthrax lethal toxin induces endothelial barrier dysfunctionConsequences and utility of the zinc-dependent metalloprotease activity of anthrax lethal toxin.Contribution of lethal toxin and edema toxin to the pathogenesis of anthrax meningitis.Development of an in vitro potency assay for anti-anthrax lethal toxin neutralizing antibodiesHighly predictive support vector machine (SVM) models for anthrax toxin lethal factor (LF) inhibitors.Inhibitors of the Metalloproteinase Anthrax Lethal Factor.MEK genomics in development and diseaseNorepinephrine increases blood pressure but not survival with anthrax lethal toxin in rats.Two hydrophobic residues can determine the specificity of mitogen-activated protein kinase docking interactions.Anthrax lethal toxin and the induction of CD4 T cell immunity.Identification of a Substrate-selective Exosite within the Metalloproteinase Anthrax Lethal Factor.Subsite specificity of anthrax lethal factor and its implications for inhibitor developmentToxoplasma gondii rhoptry discharge correlates with activation of the early growth response 2 host cell transcription factor.Anthrax lethal toxin rapidly reduces c-Jun levels by inhibiting c-Jun gene transcription and promoting c-Jun protein degradation.Involvement of domain II in toxicity of anthrax lethal factor.Surviving the passage: Non-canonical stromal targeting of an Arabidopsis mitogen-activated protein kinase kinaseInsights into the anthrax lethal factor-substrate interaction and selectivity using docking and molecular dynamics simulations.Intrinsic fluctuations, robustness, and tunability in signaling cycles.C/EBPbeta phosphorylation rescues macrophage dysfunction and apoptosis induced by anthrax lethal toxin.
P2860
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P2860
Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Anthrax lethal factor-cleavage ...... inding to their cognate MAPKs.
@en
Anthrax lethal factor-cleavage products of MAPK
@nl
type
label
Anthrax lethal factor-cleavage ...... inding to their cognate MAPKs.
@en
Anthrax lethal factor-cleavage products of MAPK
@nl
prefLabel
Anthrax lethal factor-cleavage ...... inding to their cognate MAPKs.
@en
Anthrax lethal factor-cleavage products of MAPK
@nl
P2860
P356
P1433
P1476
Anthrax lethal factor-cleavage ...... inding to their cognate MAPKs.
@en
P2093
A Jane Bardwell
Mahsa Abdollahi
P2860
P304
P356
10.1042/BJ20031382
P407
P50
P577
2004-03-01T00:00:00Z