T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation
about
Diacylglycerol kinase as a possible therapeutic target for neuronal diseasesDiacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapseDiacylglycerol Kinases in T Cell Tolerance and Effector FunctioncAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytesModulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acidSAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling.Diacylglycerol kinase-alpha phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility.Molecular Pathways: Targeting Diacylglycerol Kinase Alpha in CancerProtein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytesThe ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling.RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase.Diacylglycerol kinase β knockout mice exhibit attention-deficit behavior and an abnormal response on methylphenidate-induced hyperactivityDiacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.Phosphoinositide 3-kinase regulates plasma membrane targeting of the Ras-specific exchange factor RasGRP1.Diacylglycerol Kinase Inhibition and Vascular FunctionRegulation and Function of the RasGRP Family of Ras Activators in Blood CellsTight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development.Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse.Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.Protein kinase C and beyond.FoxO-dependent regulation of diacylglycerol kinase α gene expressionTemporal cross-talk between TCR and STAT signals for CD8 T cell effector differentiation.Diacylglycerol kinases: regulated controllers of T cell activation, function, and development.Role of diacylglycerol kinases in T cell development and function.Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta.Diacylglycerol kinases in immune cell function and self-tolerance.DGKα DNA vaccine relieves airway allergic inflammation in asthma model possibly via induction of T cell anergy.Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases.Dramatic differences in the roles in lipid metabolism of two isoforms of diacylglycerol kinase.Redundant and specialized roles for diacylglycerol kinases α and ζ in the control of T cell functions.Receptor signaling in immune cell development and function.Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation.Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling.Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha.An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in post-thymic T cells.Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane.Predominant contribution of DGKζ over DGKα in the control of PKC/PDK-1-regulated functions in T cells.Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation.
P2860
Q26863013-45E046BA-FDFA-490C-AEAA-12B3F045CEA6Q27329909-E53DB582-A282-43D3-A4F0-7FDF467C1610Q28079616-C38BF4F9-19EA-4D6C-B357-5B6FD5DA5A08Q28115537-DFB666CB-3263-4D20-B5F0-FC775C84F010Q28248440-AB368BA4-9059-45C4-8BE8-5399FB6E959DQ28301067-A929FB76-7B4B-4CB2-A4A0-288D1584BAE3Q30010214-DDD482E3-1D08-4CF0-A210-EAFF4CAE7D64Q30157891-D78891A2-9139-4618-8A64-176DD6BBCC59Q30278600-D69FBC04-23FC-476B-B138-B82F8AC432BBQ30735300-D3108246-1735-495F-BCDB-15D8B07B1179Q33894273-D06BB090-7977-4D01-8C44-10AB85363094Q34086384-36E1AD7C-63A1-4F3E-AC3F-CC544F4E316BQ34271154-4FCFE1AF-4749-4BAB-8559-47A64554D809Q34360144-3286ABE6-2A9F-491B-85A4-770A00602E45Q34752626-FFBEC229-C43C-4CDB-B904-1CB49D1B4F47Q34914993-4B07E83E-AEC2-4F05-A123-E5AE23281DB8Q35083742-37D5B67D-2286-423F-AC3E-D4C58983F7C8Q35175941-0F0EA326-601B-48A0-AD00-0C2BAEC450E2Q35551761-F22DC7C3-2E4B-4993-9C8C-B2AFCD591C82Q35785549-A2F5FE26-9522-42F3-824C-ACF8214FF6F0Q35849920-FDE7DAC9-221F-4CC9-9F94-9D4E47A252B8Q36276757-CBE20CDB-9354-4099-B618-D0BC51349A6FQ36656068-E5A4BF65-1EEF-4029-A575-D93F25DCB058Q36820360-0DDC99E8-36F1-46B7-A179-2D8B7C403095Q36946379-0C76A8F1-7184-4B3E-BC2E-1530F7D65481Q36954496-8A8D2383-BC60-4088-B017-70EAD9BC9ADFQ37257003-851D865D-36BD-4B6F-8364-1E484A959BC0Q37277764-FBA9A0B7-DA13-4A95-8974-68896D265611Q37336964-44640F7B-7893-4C40-9202-9EF661829206Q37348000-739EDA4E-03D0-4477-A9F2-C3DEBB1D49DAQ38447171-C477E0B7-AB0A-4848-B448-E980D8DCB92DQ38711461-03E995D0-2CDC-4C8A-84B0-E613465A46C2Q39889227-DFA3CAE2-AE4A-4C22-AE59-16E4F79201D4Q40075732-C338ECC4-D465-4C94-8069-733A1922025EQ40128306-2D614135-2885-4A8E-A401-D7E4466358AFQ40222415-D354570D-6DCE-481E-BD33-83EEE23659E0Q41547133-5D3342BC-0696-4652-AC10-5A2529468DE1Q42414565-14E28683-91B7-4FEA-82A3-7D108CF94D14Q42505278-7516DECE-17AF-4541-95E0-AC87A553BBBAQ42556634-4D27D87B-FB9C-450D-A7A2-9DB039EC5EE9
P2860
T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
T cell activation in vivo targ ...... mechanism for Ras attenuation
@ast
T cell activation in vivo targ ...... mechanism for Ras attenuation
@en
T cell activation in vivo targ ...... mechanism for Ras attenuation
@nl
type
label
T cell activation in vivo targ ...... mechanism for Ras attenuation
@ast
T cell activation in vivo targ ...... mechanism for Ras attenuation
@en
T cell activation in vivo targ ...... mechanism for Ras attenuation
@nl
prefLabel
T cell activation in vivo targ ...... mechanism for Ras attenuation
@ast
T cell activation in vivo targ ...... mechanism for Ras attenuation
@en
T cell activation in vivo targ ...... mechanism for Ras attenuation
@nl
P2093
P3181
P1476
T cell activation in vivo targ ...... mechanism for Ras attenuation
@en
P2093
Bérengère Pradet-Balade
Carlos Martínez-A
David R Jones
Isabel Mérida
James C Stone
Jose A Garcia-Sanz
Miguel A Sanjuán
P304
P3181
P356
10.4049/JIMMUNOL.170.6.2877
P407
P577
2003-03-15T00:00:00Z