L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system
about
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formationDJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosisMutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stabilityParkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavageInteraction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell deathDJ-1 has a role in antioxidative stress to prevent cell deathRNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathwaysDJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADDMitochondrial localization of DJ-1 leads to enhanced neuroprotectionGenetics of Parkinson diseaseEvolutionary and functional relationships within the DJ1 superfamilyParkinson's disease proteins: Novel mitochondrial targets for cardioprotectionThe 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: A member of the DJ-1/ThiJ/PfpI superfamilyStructural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1 † , ‡Crystal Structure of Filamentous Aggregates of Human DJ-1 Formed in an Inorganic Phosphate-dependent MannerUse of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimersCross Talk between Two Antioxidant Systems, Thioredoxin and DJ-1: Consequences for CancerEvidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null miceHypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.Structural effects of Parkinson's disease linked DJ-1 mutations.Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function.Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseasesDetection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase.BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity.DJ-1, PINK1, and their effects on mitochondrial pathwaysDJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex.A plant DJ-1 homolog is essential for Arabidopsis thaliana chloroplast development.Engineered disulfide bonds restore chaperone-like function of DJ-1 mutants linked to familial Parkinson's disease.Parkinson's disease: Exit toxins, enter geneticsL10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairmentsUnravelling the role of defective genes.Parkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease.DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.PRAK interacts with DJ-1 and prevents oxidative stress-induced cell death.Phenotypic and proteomic characteristics of human dental pulp derived mesenchymal stem cells from a natal, an exfoliated deciduous, and an impacted third molar tooth.Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases.The genetics of Parkinson disease.The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
P2860
Q21146396-CD366DAD-D235-4095-A65D-BD91787B1025Q24299536-19B385CD-8079-439D-836B-D7D568E17C39Q24299939-C4ACE447-1800-4B6F-8971-B8F3BCEE2D33Q24304102-BB158F97-2418-46ED-99DC-EF8C40A11275Q24306270-8BD58873-6BFB-4159-8BE2-D4DBE1590233Q24306633-4017A0E8-C108-49D1-B979-3EA61975C6D0Q24313263-7CAFD51C-6BB9-46DA-90DB-3819E95D753DQ24316876-D0323805-6BFF-40CE-BF92-94D5C23ECFE9Q24324226-CF1A5A37-6186-48EE-9C97-3CAF56135EC1Q24558967-1A3F2796-EF89-4346-AE77-0E9ACE4BC2F3Q24803493-C353DEAC-9D1F-4A99-A5FB-1070682BB09DQ26781796-42F1E633-F38C-4E1F-948C-1A8DC7026A32Q27643033-E0770353-86EB-40A8-825E-4AC0CD5E32F1Q27649496-C14D0505-B1F8-4864-9A9D-65C830DC3545Q27652523-F5AB9935-D4C7-411C-935A-B955252B8A1BQ27683814-A9EC2D6F-7432-48D7-90FF-BC9E72FF7501Q28083118-59301E03-9E11-4433-AE6C-FF8662E34AB7Q28258696-23B9A94B-16EE-4A44-884A-274FEE340AB2Q28397050-AEEFCADD-6582-4B8E-AD0A-F12A621BB266Q28507691-3B57752F-7609-49F6-9288-7797C7C66446Q28593258-ACA51881-4707-4594-950C-CCB3342D69A0Q30369057-E65077B8-8BFF-43B5-82C7-487513F54DE2Q30481530-FC36D84C-A6FC-437C-A53E-E39D5C6239B8Q33235503-D285D140-703A-498F-B82F-BEF83C17EC3DQ33466833-437B352C-656B-47AA-BB84-20DDD9ACF611Q33689625-539C8887-B351-41C8-9C3E-BCF257EE41E1Q33733264-B4D3963B-6E43-4C9B-B1F1-40FD3FE44FFAQ33905966-636582C4-3CD5-46C0-8AD3-926E2D544BEAQ34008915-2A89DE80-6BF4-48E9-A950-D6DF2E895F52Q34078603-BC876C1A-004D-4191-9F7D-A0B428C01CE6Q34140428-0F8AA3EE-29F4-4638-8AF5-B73716804515Q34145889-86B19F57-B4F3-482D-A96B-C454F53DA276Q34201811-E60A457F-2CE0-453D-BC96-050C0F78919CQ34301507-2FD1C657-9F35-4D79-96A8-2B8D433C4400Q34399382-7676F472-E5A7-4857-A25D-B1297692E1B4Q34419476-2CC83845-34C2-4F25-83F6-B47765226536Q34419494-157CD02C-70C1-4C3F-A926-89740DECA8EEQ34502221-79ECCE3A-5BAC-4CC6-A814-AB82D726CEF6Q34604083-BFB29DCA-4DE0-4357-A046-7E5DD9C1D34DQ34836156-0D77E6EC-C103-43E0-A9DF-A870402C0E53
P2860
L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system
@ast
L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system
@en
L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system
@nl
type
label
L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system
@ast
L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system
@en
L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system
@nl
prefLabel
L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system
@ast
L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system
@en
L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system
@nl
P2093
P2860
P3181
P356
P1476
L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system
@en
P2093
Chris McLendon
Craig Blackstone
David W Miller
Donald M Carter
Gary R Klinefelter
Jayanth Chandran
Julia Stadler
Melisa J Baptista
Peng-Peng Zhu
Rili Ahmad
P2860
P304
P3181
P356
10.1074/JBC.M304272200
P407
P577
2003-09-19T00:00:00Z