Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. - Wikidata - awgldk - TriplyDB

Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function.

Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function.

http://www.wikidata.org/entity/Q30481530

about

Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity Evaluation of Models of Parkinson's Disease Genetically engineered mouse models of Parkinson's disease Park7 expression influences myotube size and myosin expression in muscle Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1 Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase.Autism-relevant social abnormalities and cognitive deficits in engrailed-2 knockout mice Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice.DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function.Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.Behavioral phenotyping of mouse models of Parkinson's disease.Reactive oxygen species-mediated DJ-1 monomerization modulates intracellular trafficking involving karyopherin β2 Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neurons Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice.The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice.Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1 Animal models of the non-motor features of Parkinson's disease.Absence of DJ-1 causes age-related retinal abnormalities in association with increased oxidative stress.Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment.Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism.Differences in strength-duration curves of electrical diagnosis by physiotherapists between DJ-1 homozygous knockout and wild-type mice: a randomized controlled pilot trial Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons.Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease.Altered Ca2+ homeostasis in the skeletal muscle of DJ-1 null mice.Hexokinases link DJ-1 to the PINK1/parkin pathway.Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats.Parkinson's disease: experimental models and reality.Nrf2-ARE signals mediated the anti-oxidative action of electroacupuncture in an MPTP mouse model of Parkinson's disease.Distribution of oxidized DJ-1 in Parkinson's disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin

P2860

Q24296667-93C37F48-3449-4A99-A55B-F309F3139A03 Q24313263-FF14C7F4-1A5A-4750-A227-13E8F55CEE09 Q24323196-ECEB4D38-6561-464E-9138-29D5F8367AEE Q26772843-AC7CD597-5887-4977-A31C-BD51EEBE4B85 Q26852964-51642F8E-8EAB-42AF-A98D-F6F0C8377776 Q27314984-EA56CD13-58E9-4915-9CE5-D29E407BDA4C Q27653346-E411D4D5-EAA9-492B-A3B9-2937A6425BD0 Q30444939-FE996B37-46B5-4F0A-B67A-8863AB234515 Q30465549-6B9C9560-E4E6-4629-B644-28C26BBF9CF7 Q30494594-826E6A4F-0719-4A02-BF8E-C86B05E31E36 Q30495575-241D348D-63BA-4D2E-996F-CA7F72635842 Q30581658-E8BED6AC-A136-4E45-BA2E-A9B7D2A43FD5 Q33755817-2DC5AE84-BB33-45E6-9EA8-C8AF9BC775BC Q33820609-F9DC19ED-CC21-4344-9CA0-5D3D11247B23 Q34056577-E84A5868-A208-49EE-9B7A-041C60172423 Q34435208-946955C8-2527-4B08-ABE4-6CDD21C7B008 Q36068919-B911CA11-8ABF-4688-9B81-D7E51952E3D3 Q36103249-F0970097-3F6D-4076-9500-093009BA907C Q36158367-CE0763AF-4141-49AE-AE1C-33D1EB25ED1C Q36235578-F94B3307-442C-4FBE-B08C-BE446A436698 Q36249969-290A0D78-AC53-40A7-A302-A1E99A870B39 Q36300804-547DC5AA-1489-4BBB-B0F7-0F8DDC57B5C6 Q36553302-4860C9A9-2D49-47B2-8198-57DA239188AE Q36590693-4B50494D-5071-490E-902D-AB618A14B37A Q36999597-58750502-DB82-43AD-8CAE-10296BA2F0DF Q37220668-83949494-B671-40D8-B3CB-307A250298D5 Q37509682-ECE3C74E-E811-4351-9FB8-DA4218FC4376 Q41221578-ECF078CA-E26E-4D10-A940-B82E5F6650F6 Q42368121-7C967D55-87CA-4C27-B14A-0AF742532CCE Q42840319-E60C13C1-A23A-4721-97E8-26A566FDB1B2 Q47389506-2AD37186-9877-440C-90DB-CCA617201D38 Q47683444-AD1F7468-7172-496E-96A0-A34616782583 Q58786709-65CEEF2C-255E-4BAE-AF26-CD216C825EDA

P2860

Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function.

http://www.wikidata.org/entity/Q30481530

description

2007 nî lūn-bûn

@nan

2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Progressive behavioral deficit ...... normal nigrostriatal function.

@ast

Progressive behavioral deficit ...... normal nigrostriatal function.

@en

type

label

Progressive behavioral deficit ...... normal nigrostriatal function.

@ast

Progressive behavioral deficit ...... normal nigrostriatal function.

@en

prefLabel

Progressive behavioral deficit ...... normal nigrostriatal function.

@ast

Progressive behavioral deficit ...... normal nigrostriatal function.

@en

P1433

Q30481530-C9643EDE-1DCF-4DCF-84D2-3ED0F6C102E4

P1476

Q30481530-E3B1B19C-7DB7-4050-B632-09F702BA2119

P2093

Q30481530-02E8ECFF-D53B-4E49-929F-E6ADAEAB36F9

Q30481530-1C86B5EF-9B83-4228-AB5D-6549EFFCC747

Q30481530-1F7A6144-F66A-4C2B-821F-DF821CFEE09A

Q30481530-2368946B-BC45-47D9-80ED-045FE9C67003

Q30481530-697C2DF0-CB06-4A45-9092-FCD74672C578

Q30481530-746CE775-D18B-4B6D-A546-3F98C5DFE41A

Q30481530-7E0D26F9-D2D4-40DD-A115-F0FFF2138E91

Q30481530-9709617C-6707-4D86-8272-79D59AB90694

Q30481530-99EB34DF-F958-4606-9EA3-72937F8C0849

Q30481530-B0CB5C30-EBB7-4260-B4DD-33BBB170101B

P2860

Q30481530-0E518514-03EC-4172-96FC-FB3240AC39F9

Q30481530-0FC71E51-911E-4B60-BA4C-80C0AD77E6CF

Q30481530-13DA6BB5-D5BE-49B9-A402-91EBF6902379

Q30481530-182B86CD-64E3-4F9C-A95B-D21C01677CB0

Q30481530-234D1D8F-8DD3-4719-9AA2-9639766FE6C0

Q30481530-2DFAEFF0-A468-4439-A334-72EBF213DFE1

Q30481530-561BDA70-6246-4DAE-A278-7B1220170F06

Q30481530-598B2D08-2306-4310-90F5-B2A158860D29

Q30481530-59F85764-C9C4-444C-8CCC-F69F764B41AE

Q30481530-5A5F8856-EB81-4048-8409-903B5343D4D6

P304

Q30481530-64F1BE81-8C50-41E1-A8C8-DB600E96A870

P31

Q30481530-25368EC4-CF82-4AFC-9F3E-B072FCFBB2D8

P356

Q30481530-F60E80A8-29DF-40AA-B7C5-1BF6F15DD0FD

P433

Q30481530-6FFDCFF9-5A84-45A5-A46B-561EAFFC76B9

P478

Q30481530-A4C4578C-0873-47C4-AAA3-8E18F3854702

P577

Q30481530-FEAE0EA1-E6E7-4BCD-B05A-FCB8275E1E51

P5875

Q30481530-002E734D-DA6A-4CCC-9603-6420FBC4B7BF

P698

Q30481530-02575F18-837A-4930-8065-DFB47B587A03

P932

Q30481530-6CB2F61E-1508-492D-BA54-CACCB4917208

P356

J.NBD.2007.11.011

P1433

Neurobiology of Disease

P1476

Progressive behavioral deficit ...... normal nigrostriatal function.

@en

P2093

Agustin Zapata

http://www.w3.org/2001/XMLSchema#string

Ahmet Höke

http://www.w3.org/2001/XMLSchema#string

Donald L Price

http://www.w3.org/2001/XMLSchema#string

Fiona M Laird

http://www.w3.org/2001/XMLSchema#string

Huaibin Cai

http://www.w3.org/2001/XMLSchema#string

Jacqueline N Crawley

http://www.w3.org/2001/XMLSchema#string

Jayanth S Chandran

http://www.w3.org/2001/XMLSchema#string

Kathleen R Bailey

http://www.w3.org/2001/XMLSchema#string

Matthew P Galloway

http://www.w3.org/2001/XMLSchema#string

Mika Shimoji

http://www.w3.org/2001/XMLSchema#string

P2860

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

Gait dynamics in mouse models of Parkinson's disease and Huntington's disease.

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration

Inbred strain differences in prepulse inhibition of the mouse startle response

Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1

Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase

Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice

P304

505-514

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.NBD.2007.11.011

http://www.w3.org/2001/XMLSchema#string

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

29

http://www.w3.org/2001/XMLSchema#string

P577

2007-12-04T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5664090

http://www.w3.org/2001/XMLSchema#string

P698

18187333

http://www.w3.org/2001/XMLSchema#string

P932

2271119

http://www.w3.org/2001/XMLSchema#string