PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation
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Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesisNonsense mutations of the bHLH transcription factor TWIST2 found in Setleis Syndrome patients cause dysregulation of periostinAltered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalitiesFluorescence resonance energy transfer (FRET) as a method to calculate the dimerization strength of basic Helix-Loop-Helix (bHLH) proteinsPhosphopeptide mapping of proteins ectopically expressed in tissue culture cell linesThe emerging role of Twist proteins in hematopoietic cells and hematological malignanciesPhosphorylation regulates OLIG2 cofactor choice and the motor neuron-oligodendrocyte fate switchPhosphorylation of the Twist1-family basic helix-loop-helix transcription factors is involved in pathological cardiac remodelingTargeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract developmentHand2 determines the noradrenergic phenotype in the mouse sympathetic nervous systemAn absence of Twist1 results in aberrant cardiac neural crest morphogenesisBMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathwaysEndothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identityMice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.DNA damage-induced phosphorylation of the human telomere-associated protein TRF2.Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration.Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis.Redundant or separate entities?--roles of Twist1 and Twist2 as molecular switches during gene transcriptionA tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins.Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cellsCombinatorial transcriptional interaction within the cardiac neural crest: a pair of HANDs in heart formation.B56δ-related protein phosphatase 2A dysfunction identified in patients with intellectual disability.Target-dependent inhibition of sympathetic neuron growth via modulation of a BMP signaling pathwayGene replacement strategies to test the functional redundancy of basic helix-loop-helix transcription factor.Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neuronsRegulation of cardiac excitation and contraction by p21 activated kinase-1Phosphoregulation of Twist1 provides a mechanism of cell fate control.A twist of insight - the role of Twist-family bHLH factors in development.Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases.A bHLH code for cardiac morphogenesis.Functions of B56-containing PP2As in major developmental and cancer signaling pathways.Hand factors as regulators of cardiac morphogenesis and implications for congenital heart defectsTwist factor regulation of non-cardiomyocyte cell lineages in the developing heart.A tale with a Twist: a developmental gene with potential relevance for metabolic dysfunction and inflammation in adipose tissue.PP2A as a master regulator of the cell cycle.miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A.Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis.Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities.Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability.
P2860
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P2860
PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation
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2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
PKA, PKC, and the protein phos ...... fic transcriptional regulation
@ast
PKA, PKC, and the protein phos ...... fic transcriptional regulation
@en
PKA, PKC, and the protein phos ...... fic transcriptional regulation
@nl
type
label
PKA, PKC, and the protein phos ...... fic transcriptional regulation
@ast
PKA, PKC, and the protein phos ...... fic transcriptional regulation
@en
PKA, PKC, and the protein phos ...... fic transcriptional regulation
@nl
prefLabel
PKA, PKC, and the protein phos ...... fic transcriptional regulation
@ast
PKA, PKC, and the protein phos ...... fic transcriptional regulation
@en
PKA, PKC, and the protein phos ...... fic transcriptional regulation
@nl
P2093
P1433
P1476
PKA, PKC, and the protein phos ...... fic transcriptional regulation
@en
P2093
Anthony B Firulli
Beth A Firulli
David M Virshup
Jennifer R McDaid
Karen M Dionne
Leanne McIlreavey
Marthe J Howard
Peter Cserjesi
Victoria E Centonze
P304
P407
P577
2003-11-01T00:00:00Z